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NSC 66811

Cat. No. 2936 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2936 has been discontinued.

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说明： MDM2 antagonist. Disrupts MDM2-p53 interaction
化学名： 2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol
纯度： ≥97% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for NSC 66811

Potent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.

技术数据 for NSC 66811

分子量 340.42
公式 C23H20N2O
储存 Store at +4°C
纯度 ≥97% (HPLC)
CAS Number 6964-62-1
PubChem ID 248986
InChI Key WEENRMPCSWFMTE-UHFFFAOYSA-N
Smiles CC2=NC1=C(O)C(C(NC4=CC=CC=C4)C3=CC=CC=C3)=CC=C1C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

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参考文献 for NSC 66811

参考文献是支持产品生物活性的出版物。

Lu et al (2006) Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J.Med.Chem. 49 3759 PMID: 16789731

Shangary and Shaomeng (2009) Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Ann.Rev.Pharmacol.Toxicol. 49 223

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关键词: NSC 66811, NSC 66811 supplier, MDM2, antagonists, Disrupts, MDM2-p53, interaction, Transcription, Factors, NSC66811, p53, Ubiquitin, E3, Ligases, 2936, Tocris Bioscience

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