主页 / 药理学 / Enzymes / Ligases / Ubiquitin/Ubl E2 Conjugating Enzymes / Ubiquitin/Ubl E2 Conjugating Enzyme Inhibitors / NSC 697923

NSC 697923

Cat. No. 4858 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4858 has been discontinued.

View all Ubiquitin/Ubl E2 Conjugating Enzymes products.
说明： Selective UBE2N inhibitor
化学名： 2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for NSC 697923

NSC 697923 is a selective inhibitor of the E2 ubiquitin (Ub) conjugating enzyme UBE2N (Ubc13). Inhibits UBE2N-Ub conjugation and activity of the UBE2N-Ueva1A complex. Has no effect on UbcH5c activity. Inhibits NF-κB activation in diffuse large B-cell lymphoma (DLBCL) cells. Inhibits cell growth and induces apoptosis in DLBCL and neuroblastoma (NB) cell lines. Supresses NB cell xenograft tumor growth in vivo.

技术数据 for NSC 697923

分子量 267.26
公式 C11H9NO5S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 343351-67-7
PubChem ID 394449
InChI Key GAUHIPWCDXOLCZ-UHFFFAOYSA-N
Smiles CC(C=C2)=CC=C2S(C1=CC=C([N+]([O-])=O)O1)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for NSC 697923

参考文献是支持产品生物活性的出版物。

Pulvino et al (2012) Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A. Blood 120 1668 PMID: 22791293

Cheng et al (2014) A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 5 e1079 PMID: 24556694

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Ubiquitin/Ubl E2 Conjugating Enzyme Inhibitors

关键词: NSC 697923, NSC 697923 supplier, NSC697923, E2, ubiquitin, conjugating, enzymes, Ubc13, Uev1A, NF-KB, inhibitors, proliferation, survival, lymphoma, UBE2N, NFκB, NFkappaB, antitumor, inhibits, Post-translational, Modifications, Ubiquitin/Ubl, Conjugating, Enzymes, 4858, Tocris Bioscience

篇 NSC 697923 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 NSC 697923 的引用文献。

NSC 697923 的评论

目前没有该产品的评论。 Be the first to review NSC 697923 and earn rewards!

Have you used NSC 697923?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review