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Submit ReviewNutlin-3
说明： MDM2 antagonist; inhibits MDM2-p53 interaction
化学名： (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one
纯度： ≥98% (HPLC)
生物活性 for Nutlin-3
Nutlin-3 is a MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.
许可信息
Sold under license from F. Hoffmann-La Roche Ltd.
技术数据 for Nutlin-3
| 分子量 | 581.49 |
| 公式 | C30H30Cl2N4O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 548472-68-0 |
| PubChem ID | 16755649 |
| InChI Key | BDUHCSBCVGXTJM-IZLXSDGUSA-N |
| Smiles | ClC1=CC=[C@@]([C@@H]3[C@@H](N(C(N5CC(NCC5)=O)=O)C(C4=CC=C(OC)C=C4OC(C)C)=N3)[C@]2=CC=C(Cl)C=C2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Nutlin-3
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 58.15 | 100 | |
| ethanol | 58.15 | 100 |
制备储备液 for Nutlin-3
以下数据基于产品分子量 581.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.72 mL | 8.6 mL | 17.2 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.44 mL |
| 10 mM | 0.17 mL | 0.86 mL | 1.72 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
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产品说明书 for Nutlin-3
参考文献 for Nutlin-3
参考文献是支持产品生物活性的出版物。
Vassilev et al (2004) In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 844 PMID: 14704432
If you know of a relevant reference for Nutlin-3, please let us know.
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关键词: Nutlin-3, Nutlin-3 supplier, Nutlin3, p53, activator, MDM2, antagonist, antagonists, p53-MDM2, Ubiquitin, E3, Ligases, 3984, Tocris Bioscience
8 篇 Nutlin-3 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Nutlin-3 的部分引用包括：
Peter et al (2020) Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway. Life Sci Alliance 3 PMID: 32651191
Daniel P et al (2021) Replication stress promotes cell elimination by extrusion. Nature 593 591-596 PMID: 33953402
Yang et al (2016) A redox mechanism underlying nucleolar stress sensing by nucleophosmin. Nat Commun 7 13599 PMID: 27886181
Keeva et al (2018) Discovery and characterization of highly potent and selective allosteric USP7 inhibitors. Nat Chem Biol 14 118-125 PMID: 29200206
Alan R et al (2013) Small molecule induced reactivation of mutant p53 in cancer cells. Nucleic Acids Res 41 6034-44 PMID: 23630318
Gergely et al (2022) Comparison of Different Clinical Chemotherapeutical Agents' Toxicity and Cell Response on Mesenchymal Stem Cells and Cancer Cells. Cells 11 PMID: 36230904
Norlin et al (2018) The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Development 145 PMID: 29180572
Bussey et al (2016) Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma. J Zhejiang Univ Sci B 5 1 PMID: 26754547
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Nutlin-3 的评论
平均评分: 5 (Based on 1 Review.)
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In vitro cell treatment using Nutlin (Cat. No. 3984).
By
Anonymous on 01/08/2018
分析类型： In Vitro
种属： Human
It worked perfectly at 10microM concentration for 48 hours.
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