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PCI 29732

Cat. No. 5012 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent BTK inhibitor
化学名： 1-Cyclopentyl-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PCI 29732

PCI 29732 is a potent BTK inhibitor (IC50 = 0.3 nM). Blocks B cell antigen receptor (BCR)-mediated gene expression in CD20+ B cells.

化合物库 for PCI 29732

PCI 29732 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PCI 29732

分子量 371.44
公式 C22H21N5O
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 330786-25-9
PubChem ID 22347110
InChI Key GMJUPMONHWAZCP-UHFFFAOYSA-N
Smiles NC1=C2C(N(C4CCCC4)N=C2C3=CC=C(OC5=CC=CC=C5)C=C3)=NC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PCI 29732

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.14 100
ethanol 18.57 50

制备储备液 for PCI 29732

以下数据基于产品分子量 371.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for PCI 29732

参考文献是支持产品生物活性的出版物。

Honigberg et al (2010) The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc.Natl.Acad.Sci.U.S.A. 107 13075 PMID: 20615965

Krishnamurty et al (2013) Active site profiling reveals coupling between domains in SRC-family kinases. Nat.Chem.Biol. 9 43 PMID: 23143416

If you know of a relevant reference for PCI 29732, please let us know.

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关键词: PCI 29732, PCI 29732 supplier, PCI29732, Brutons, Tyrosine, Kinase, (BTK), 5012, Tocris Bioscience

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