PD 166285 dihydrochloride

Cat. No. 3785 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent Src inhibitor; also inhibits FGFR1, PDGFRβ and Wee1

化学名： 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride

纯度： ≥99% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PD 166285 dihydrochloride

PD 166285 dihydrochloride is a potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β (PDGFRβ) (IC₅₀ values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G₂ checkpoint.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for PD 166285 dihydrochloride

PD 166285 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for PD 166285 dihydrochloride

分子量	585.35
公式	C₂₆H₂₇Cl₂N₅O₂.2HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	212391-63-4
PubChem ID	9916391
InChI Key	NADLBPWBFGTESN-UHFFFAOYSA-N
Smiles	CN(C1=NC(NC4=CC=C(OCCN(CC)CC)C=C4)=NC=C1C=C2C3=C(Cl)C=CC=C3Cl)C2=O.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PD 166285 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	58.53	100

制备储备液 for PD 166285 dihydrochloride

以下数据基于产品分子量 585.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.71 mL	8.54 mL	17.08 mL
5 mM	0.34 mL	1.71 mL	3.42 mL
10 mM	0.17 mL	0.85 mL	1.71 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

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产品说明书 for PD 166285 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PD 166285 dihydrochloride

参考文献是支持产品生物活性的出版物。

Panek et al (1997) In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor. J.Pharmacol.Exp.Ther. 283 1433 PMID: 9400019

Wang et al (2001) Radiosensitization of p53 mutant cells by PD0166285, a novel G₂ checkpoint abrogator. Cancer Res. 61 8211 PMID: 11719452

Hashimoto et al (2006) Cell cycle regulation by the Wee1 inhibitor PD0166285, Pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line. BMC Cancer 6 292 PMID: 17177986

If you know of a relevant reference for PD 166285 dihydrochloride, please let us know.

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关键词: PD 166285 dihydrochloride, PD 166285 dihydrochloride supplier, Src, FGFR, PDGFRbeta, PDGFRb, PDGFRβ, PDGFR, Wee1, inhibitors, inhibits, Pfizer, RTKs, receptor, tyrosine, kinases, fibroblast, platelet, growth, factors, PD166285, Kinases, Checkpoint, Control, 3785, Tocris Bioscience

2 篇 PD 166285 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PD 166285 dihydrochloride 的部分引用包括：

Gaffré et al (2011) A critical balance between Cyclin B synthesis and Myt1 activity controls meiosis entry in Xenopus oocytes. Toxicol Lett 138 3735 PMID: 21795279

Hui et al (2021) Echinoderm Microtubule Associated Protein Like 1 Is Indispensable for Oocyte Spindle Assembly and Meiotic Progression in Mice. Front Cell Dev Biol 9 687522 PMID: 34124073

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