PD 184352

Name: PD 184352
Brand: Tocris Bioscience
SKU: 4237
Rating: 5 (1 reviews)

Cat. No. 4237 4 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective MEK inhibitor

别名： CI-1040

化学名： 2-[(2-Chloro-4-iodophenyl)amino]-N-cyclopropylmethoxy)-3,4-difluorobenzamide

纯度： ≥98% (HPLC)

说明书

引用文献 (4)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PD 184352

PD 184352 is a selective MEK inhibitor (K_i = 300 nM in vitro). Suppresses FGF-mediated angiogenesis in vivo and decreases VEGF expression. Enhances the therapeutic efficacy of taxol (Cat. No. 1097) in vivo. Orally active.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

技术数据 for PD 184352

分子量	478.66
公式	C₁₇H₁₄ClF₂IN₂O₂
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	212631-79-3
PubChem ID	6918454
InChI Key	GFMMXOIFOQCCGU-UHFFFAOYSA-N
Smiles	FC1=C(NC2=CC=C(I)C=C2Cl)C(C(NOCC3CC3)=O)=CC=C1F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PD 184352

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	47.87	100
	ethanol	11.97	25

制备储备液 for PD 184352

以下数据基于产品分子量 478.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.09 mL	10.45 mL	20.89 mL
5 mM	0.42 mL	2.09 mL	4.18 mL
10 mM	0.21 mL	1.04 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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产品说明书 for PD 184352

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PD 184352

参考文献是支持产品生物活性的出版物。

Allen et al (2003) CI-1040 (PD184252), a targeted signal transduction inhibitor of MEK (MAPKK). Semin.Oncol. 30 105 PMID: 14613031

McDaid et al (2005) Enhancement of the therapeutic efficacy of Tax. by the mitogen-activated protein kinase kinase inhibitor CI-1040 in nude mice bearing human heterotransplants. Cancer Res. 65 2854 PMID: 15805287

Solit et al (2006) BRAF mutation predicts sensitivity to MEK inhibition. Nature 439 358 PMID: 16273091

If you know of a relevant reference for PD 184352, please let us know.

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关键词: PD 184352, PD 184352 supplier, pfizer, mek1, mek2, mkk1, mkk2, inhibitors, inhibits, selective, mapk, signaling, signalling, map, kinases, PD184352, CI1040, CI-1040, MEK, 4237, Tocris Bioscience

4 篇 PD 184352 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PD 184352 的部分引用包括：

Wouters et al (2014) Central role for protein kinase C in oxyt. and epidermal growth factor stimulated cyclooxygenase 2 expression in human myometrial cells. Genes Cancer 7 357 PMID: 24916153

Martin et al (2014) miR-155 induced transcriptome changes in the MCF-7 breast cancer cell line leads to enhanced mitogen activated protein kinase signaling. J Exp Bot 5 353 PMID: 25352952

Wang et al (2015) Activation of protein synthesis in mouse uterine epithelial cells by OE-17β is mediated by a PKC-ERK1/2-mTOR signaling pathway. BMC Res Notes 112 E1382 PMID: 25733860

W Michael et al (2013) Subtype-specific MEK-PI3 kinase feedback as a therapeutic target in pancreatic adenocarcinoma. Mol Cancer Ther 12 2213-25 PMID: 23918833

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PD 184352 的评论

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The role of ERK pathway in LPA induced pro-inflammatory phenotype in microglia cells.

By Joanna Plastira on 06/08/2019

分析类型： In Vitro

种属： Mouse

细胞系/组织： Primary murine microglia cells

The role of MAPK pathways (JNK, p38 and ERK) was studied in the LPA induced pro-inflammatory phenotype in microglia. In this case cells were incubated for the indicated time points with LPA (1µM) in the presence or absence of PD98059 (10µM) or PD184352 (10µM). A series of assays were performed. The effect of PD1843452 was more prominent in slightly inhibiting the expression of pp65.

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for PD 184352

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.