PD 407824

Pricing Availability   Qty
说明: Potent and selective inhibitor of Chk1 and Wee1
化学名: 9-Hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
纯度: ≥98% (HPLC)
说明书
引用文献 (3)
评论
文献 (1)

生物活性 for PD 407824

PD 407824 is a potent and selective inhibitor of checkpoint kinases Chk1 and Wee1 (IC50 values are 47 and 97 nM respectively). Displays selectivity over a range of other protein kinases; IC50 values are 3.4, 3.75, > 5, > 50, > 50 and > 50 μM for PKC, CDK4, other CDKs, c-Src, PDGFR and FGFR respectively. Also sensitizes hESCs to BMP4 to induce differentiation.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for PD 407824

PD 407824 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for PD 407824

分子量 328.32
公式 C20H12N2O3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 622864-54-4
PubChem ID 4369491
InChI Key IAUZTOZLTFSMIE-UHFFFAOYSA-N
Smiles OC1=CC2=C(NC3=C2C2=C(C(=O)NC2=O)C(=C3)C2=CC=CC=C2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PD 407824

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.83 100
ethanol 8.2 25

制备储备液 for PD 407824

以下数据基于产品分子量 328.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.05 mL 15.23 mL 30.46 mL
5 mM 0.61 mL 3.05 mL 6.09 mL
10 mM 0.3 mL 1.52 mL 3.05 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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查看全部 Checkpoint Kinase Inhibitors

关键词: PD 407824, PD 407824 supplier, Selective, inhibitors, inhibits, Chk1, Wee1, Checkpoint, Control, Kinases, PD407824, Pfizer, BMP4, sensitizes, sensitizers, BMP, and, Other, Activin, Receptors, ESCs, iPSC, 2694, Tocris Bioscience

3 篇 PD 407824 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PD 407824 的部分引用包括:

Azorsa et al (2009) Synthetic lethal RNAi screening identifies sensitizing targets for gemcit. therapy in pancreatic cancer. J Transl Med 7 43 PMID: 19519883

Kishikawa et al (2015) Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine. Oncotarget 6 8339 PMID: 25826076

Pouliot et al (2012) Cisplatin sensitivity mediated by WEE1 and CHK1 is mediated by miR-155 and the miR-15 family. Cancer Res 72 5945 PMID: 22942255


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