Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPD 407824 is a potent and selective inhibitor of checkpoint kinases Chk1 and Wee1 (IC50 values are 47 and 97 nM respectively). Displays selectivity over a range of other protein kinases; IC50 values are 3.4, 3.75, > 5, > 50, > 50 and > 50 μM for PKC, CDK4, other CDKs, c-Src, PDGFR and FGFR respectively. Also sensitizes hESCs to BMP4 to induce differentiation.
Sold for research purposes under agreement from Pfizer Inc.
PD 407824 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
分子量 | 328.32 |
公式 | C20H12N2O3 |
储存 | Store at +4°C |
纯度 | ≥98% (HPLC) |
CAS Number | 622864-54-4 |
PubChem ID | 4369491 |
InChI Key | IAUZTOZLTFSMIE-UHFFFAOYSA-N |
Smiles | OC1=CC2=C(NC3=C2C2=C(C(=O)NC2=O)C(=C3)C2=CC=CC=C2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 32.83 | 100 | |
ethanol | 8.2 | 25 |
以下数据基于产品分子量 328.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.05 mL | 15.23 mL | 30.46 mL |
5 mM | 0.61 mL | 3.05 mL | 6.09 mL |
10 mM | 0.3 mL | 1.52 mL | 3.05 mL |
50 mM | 0.06 mL | 0.3 mL | 0.61 mL |
参考文献是支持产品生物活性的出版物。
Squire et al (2005) Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation. Structure 13 541 PMID: 15837193
Palmer et al (2006) 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenylring substitutions. J.Med.Chem. 49 4896 PMID: 16884302
Feng et al (2016) Discovery of a small-molecule BMP sensitizer for human embryonic stem cell differentiation. Cell Rep. 15 2063 PMID: 27210748
If you know of a relevant reference for PD 407824, please let us know.
关键词: PD 407824, PD 407824 supplier, Selective, inhibitors, inhibits, Chk1, Wee1, Checkpoint, Control, Kinases, PD407824, Pfizer, BMP4, sensitizes, sensitizers, BMP, and, Other, Activin, Receptors, ESCs, iPSC, 2694, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 PD 407824 的部分引用包括:
Azorsa et al (2009) Synthetic lethal RNAi screening identifies sensitizing targets for gemcit. therapy in pancreatic cancer. J Transl Med 7 43 PMID: 19519883
Kishikawa et al (2015) Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine. Oncotarget 6 8339 PMID: 25826076
Pouliot et al (2012) Cisplatin sensitivity mediated by WEE1 and CHK1 is mediated by miR-155 and the miR-15 family. Cancer Res 72 5945 PMID: 22942255
您是否知道使用了 Tocris PD 407824 的优秀论文? 请告知我们.
目前没有该产品的评论。 Be the first to review PD 407824 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.