Perifosine

Cat. No. 6087 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： PKB/Akt inhibitor; also modulates K_v2.1 current

别名： KRX-0401

化学名： Octadecyl-(1,1-dimethyl-4-piperidylio) phosphate

纯度： ≥99% (HPLC)

引用文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Perifosine

Perifosine is a PKB/Akt inhibitor; accumulates in and reorganizes lipid rafts disrupting Akt signaling. Also inhibits MAPK pathway and induces autophagy. Induces apoptosis in leukemia cell lines. Decreases K_v2.1 current amplitude by modulating its inactivation gating. Antitumor. Orally bioavailable.

技术数据 for Perifosine

分子量	461.66
公式	C₂₅H₅₂NO₄P
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	157716-52-4
PubChem ID	148177
InChI Key	SZFPYBIJACMNJV-UHFFFAOYSA-N
Smiles	CCCCCCCCCCCCCCCCCCOP([O-])(OC1CC[N+](C)(CC1)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Perifosine

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	46.17	100
	ethanol	46.17	100

制备储备液 for Perifosine

以下数据基于产品分子量 461.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.17 mL	10.83 mL	21.66 mL
5 mM	0.43 mL	2.17 mL	4.33 mL
10 mM	0.22 mL	1.08 mL	2.17 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for Perifosine

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Perifosine

参考文献是支持产品生物活性的出版物。

Delgado-Ramírez et al (2016) Modulation of the voltage-gated potassium channel K_v2.1 by the anti-tumor alkylphospholipid perifosine. Pharmacol Rep. 68 457 PMID: 26922553

Fu et al (2009) Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res. 69 8967 PMID: 19920197

Tazzari et al (2008) Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells. Cancer Res. 68 9394 PMID: 19010914

If you know of a relevant reference for Perifosine, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Akt (Protein Kinase B) Inhibitors

关键词: Perifosine, Perifosine supplier, PKB, Akt, inhibitors, inhibts, lipid, rafts, MAPK, autophagy, apoptosis, induces, inducers, Kv2.1, antitumor, orally, bioavailable, inward, rectifier, potassium, current, KRX-0401, (Protein, Kinase, B), Protein, B/Akt, Autophagy, Voltage-Gated, Potassium, Channels, 6087, Tocris Bioscience

1 篇 Perifosine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Perifosine 的部分引用包括：

George et al (2021) Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis. Cell Rep 35 109168 PMID: 34038728

您是否知道使用了 Tocris Perifosine 的优秀论文？请告知我们.

Perifosine 的评论

目前没有该产品的评论。 Be the first to review Perifosine and earn rewards!

Have you used Perifosine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Pathways for Perifosine

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.