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PF 04691502

Cat. No. 4820 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4820 has been discontinued.

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说明： Potent and selective dual PI 3-K/mTOR inhibitor
化学名： 2-Amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxy-3-pyridinyl)-4-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for PF 04691502

PF 04691502 is a potent and selective dual ATP-competitive PI 3-K/mTOR inhibitor (Ki values are 1.6, 1.8, 1.9, 2.1 and 16 nM for human PI 3-K δ, α, γ, β, and mTOR, respectively). Displays no significant inhibitory activity at more than 80 protein kinases (concentration ≥ 10 μM) including hVps34, PI 3-K downstream kinases, and MAPK family members. Orally bioavailable. Induces robust cell cycle arrest at the G1 phase in U87MG cancer cells and antitumor activity in SKOV3 ovarian cancer xenograft models.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for PF 04691502

PF 04691502 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for PF 04691502

分子量 425.48
公式 C22H27N5O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1013101-36-4
PubChem ID 25033539
InChI Key XDLYKKIQACFMJG-UHFFFAOYSA-N
Smiles O=C2C(C4=CC=C(OC)N=C4)=CC1=C(C)N=C(N)N=C1N2[C@@H]3CC[C@@H](OCCO)CC3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for PF 04691502

参考文献是支持产品生物活性的出版物。

Yuan et al (2011) PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity. Mol.Cancer Ther. 10 2189 PMID: 21750219

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关键词: PF 04691502, PF 04691502 supplier, PF04691502, phosphoinositide, 3-kinases, PI, 3-K/mTOR, mammalian, Target, Rapamycin, FRAP, FK506, binding, protein, 12, FKBP12, rapamycin, associated, cell, cycle, antitumor, 3-Kinase, mTOR, 4820, Tocris Bioscience

1 篇 PF 04691502 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PF 04691502 的部分引用包括：

Carsten et al (2017) Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia. Oncotarget 8 29187-29201 PMID: 28418873

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