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PF 05175157

Cat. No. 5790 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent acetyl-CoA carboxylase (ACC) 1 and 2 inhibitor
化学名： 1,4-Dihydro-1'-[2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PF 05175157

PF 05175157 is an potent acetyl-CoA carboxylase (ACC) 2 and 1 inhibitor (IC50 values are 45 and 98 nM, respectively). Reduces hepatic and skeletal muscle malonyl-CoA levels in rats. Also inhibits hepatic de novo lipogenesis and reduces whole body respiratory exchange ratio in rats. Orally bioavailable.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

技术数据 for PF 05175157

分子量 405.49
公式 C23H27N5O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1301214-47-0
PubChem ID 52934180
InChI Key BDXXSFOJPYSYOC-UHFFFAOYSA-N
Smiles O=C(C4=CC=C(N=C(C)N5)C5=C4)N1CCC(CC(C=NN3C(C)C)=C3C(C2)=O)2CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PF 05175157

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 20.27 50
ethanol 8.11 20

制备储备液 for PF 05175157

以下数据基于产品分子量 405.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.93 mL 24.66 mL 49.32 mL
2.5 mM 0.99 mL 4.93 mL 9.86 mL
5 mM 0.49 mL 2.47 mL 4.93 mL
25 mM 0.1 mL 0.49 mL 0.99 mL

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产品说明书 for PF 05175157

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for PF 05175157

参考文献是支持产品生物活性的出版物。

Griffith et al (2014) Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes. J.Med.Chem. 57 10512 PMID: 25423286

If you know of a relevant reference for PF 05175157, please let us know.

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关键词: PF 05175157, PF 05175157 supplier, PF05175157, Acetyl, CoA, carboxylase, 1, 2, inhibitors, inhibits, ACC1, ACC2, potent, orally, bioavailable, type, diabetes, mellitus, Other, Ligases, Lipid, Metabolism, 5790, Tocris Bioscience

1 篇 PF 05175157 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PF 05175157 的部分引用包括：

Lien et al (2021) Low glycaemic diets alter lipid metabolism to influence tumour growth. Nature 599 302 PMID: 34671163

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