PF 3758309 dihydrochloride

Cat. No. 6005 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent PAK4 inhibitor; orally available

化学名： N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide dihydrochloride

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PF 3758309 dihydrochloride

PF 3758309 dihydrochloride is a potent PAK4 inhibitor (IC₅₀ = 1.3 nM; K_d = 2.7 nM). Inhibits proliferation and anchorage-independent growth of a panel of tumor cell lines in vitro. Suppresses growth of human HCT116 and A549 tumor cell xenografts in mice. Orally available.

许可信息

Sold for research purposes under agreement from Pfizer Inc

External Portal Information for PF 3758309 dihydrochloride

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 3758309 is reviewed on the Chemical Probes website.

化合物库 for PF 3758309 dihydrochloride

PF 3758309 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PF 3758309 dihydrochloride

分子量	563.55
公式	C₂₅H₃₀N₈OS.2HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
PubChem ID	91885498
InChI Key	BTVSNRMSUYBDRT-JQDLGSOUSA-N
Smiles	CN(C[C@H](C1=CC=CC=C1)NC(N2CC3=C(C2(C)C)NN=C3NC4=C5SC=CC5=NC(C)=N4)=O)C.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PF 3758309 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	56.35	100
	DMSO	56.35	100

制备储备液 for PF 3758309 dihydrochloride

以下数据基于产品分子量 563.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.77 mL	8.87 mL	17.74 mL
5 mM	0.35 mL	1.77 mL	3.55 mL
10 mM	0.18 mL	0.89 mL	1.77 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

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产品说明书 for PF 3758309 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PF 3758309 dihydrochloride

参考文献是支持产品生物活性的出版物。

Murray et al (2010) Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc.Natl.Acad.Sci.U.S.A. 107 9446 PMID: 20439741

If you know of a relevant reference for PF 3758309 dihydrochloride, please let us know.

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关键词: PF 3758309 dihydrochloride, PF 3758309 dihydrochloride supplier, PF3758309, dihydrochloride, Potent, PAK4, inhibitors, inhibits, orally, available, 89044_15_0, chemical, probes, P21-activated, Kinases, 6005, Tocris Bioscience

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