PF 4708671

Cat. No. 4032 18 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： S6K1 inhibitor

化学名： 2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole

纯度： ≥98% (HPLC)

引用文献 (18)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PF 4708671

PF 4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) (K_i = 20 nM; IC₅₀ = 160 nM). Suppresses the S6K1-mediated phosphorylation of S6, Rictor and mTOR in response to IGF1; displays no effect on the activity of RSK and MSK in vivo. Exhibits no significant inhibition of S6K2 or other AGC kinases (e.g. Akt, PKA and ROCK) in vitro.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for PF 4708671

PF 4708671 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for PF 4708671

分子量	390.41
公式	C₁₉H₂₁F₃N₆
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1255517-76-0
PubChem ID	51371303
InChI Key	FBLPQCAQRNSVHB-UHFFFAOYSA-N
Smiles	CCC(C=NC=N2)=C2N1CCN(CC4=NC3=CC(C(F)(F)F)=CC=C3N4)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PF 4708671

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	19.52	50
	ethanol	19.52	50

制备储备液 for PF 4708671

以下数据基于产品分子量 390.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	5.12 mL	25.61 mL	51.23 mL
2.5 mM	1.02 mL	5.12 mL	10.25 mL
5 mM	0.51 mL	2.56 mL	5.12 mL
25 mM	0.1 mL	0.51 mL	1.02 mL

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产品说明书 for PF 4708671

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PF 4708671

参考文献是支持产品生物活性的出版物。

Pearce et al (2010) Characterisation of PF-4708671 a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem.J. 431 245 PMID: 20704563

If you know of a relevant reference for PF 4708671, please let us know.

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