PF 4800567 hydrochloride

Cat. No. 4281 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective casein kinase 1ε inhibitor

化学名： 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride

纯度： ≥99% (HPLC)

引用文献 (5)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PF 4800567 hydrochloride

PF 4800567 hydrochloride is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC₅₀ values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

External Portal Information for PF 4800567 hydrochloride

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 4800567 is reviewed on the chemical probes website.

化合物库 for PF 4800567 hydrochloride

PF 4800567 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PF 4800567 hydrochloride

分子量	396.27
公式	C₁₇H₁₈ClN₅O₂.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	1391052-28-0
PubChem ID	71751553
InChI Key	QZXZQMUZEHTFHD-UHFFFAOYSA-N
Smiles	NC1=C(C(COC4=CC(Cl)=CC=C4)=NN2C3CCOCC3)C2=NC=N1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PF 4800567 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	39.63	100

制备储备液 for PF 4800567 hydrochloride

以下数据基于产品分子量 396.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.52 mL	12.62 mL	25.24 mL
5 mM	0.5 mL	2.52 mL	5.05 mL
10 mM	0.25 mL	1.26 mL	2.52 mL
50 mM	0.05 mL	0.25 mL	0.5 mL

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产品说明书 for PF 4800567 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PF 4800567 hydrochloride

参考文献是支持产品生物活性的出版物。

Walton et al (2009) Selective inhibition of casein kinase 1ε minimally alters circadian clock period. J.Pharmacol.Exp.Ther. 330 430 PMID: 19458106

Etchegaray et al (2010) Casein kinase 1 delta (CK1δ) regulates period length of the mouse suprachiasmatic circadian clock in vitro. PLoS One 5 e10303 PMID: 20421981

Meng et al (2010) Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes. Proc.Natl.Acad.Sci.USA 107 15240 PMID: 20696890

If you know of a relevant reference for PF 4800567 hydrochloride, please let us know.

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