PF 670462

Cat. No. 3316 12 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective CK1ε and CK1δ inhibitor

化学名： 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride

纯度： ≥99% (HPLC)

引用文献 (12)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PF 670462

PF 670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC₅₀ values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC₅₀ = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.

化合物库 for PF 670462

PF 670462 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for PF 670462

分子量	410.32
公式	C₁₉H₂₀FN₅.2HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	950912-80-8
PubChem ID	51049607
InChI Key	PSNKGVAXBSAHCH-UHFFFAOYSA-N
Smiles	NC1=NC=CC(C2=C(C4=CC=C(F)C=C4)N=CN2C3CCCCC3)=N1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PF 670462

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	41.03	100

制备储备液 for PF 670462

以下数据基于产品分子量 410.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.44 mL	12.19 mL	24.37 mL
5 mM	0.49 mL	2.44 mL	4.87 mL
10 mM	0.24 mL	1.22 mL	2.44 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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产品说明书 for PF 670462

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PF 670462

参考文献是支持产品生物活性的出版物。

Badura et al (2007) An inhibitor of casein kinase Iε induces phase delays in circadian rhythms under free-running and entrained conditions. J.Pharmacol.Exp.Ther. 322 730 PMID: 17502429

Bryant et al (2009) A role for casein kinase 1 epsilon in the locomotor stimulant response to metha. Psychopharmacology 203 703 PMID: 19050854

Sprose et al (2009) Inhibition of casein kinase I ε/δ produces phase shifts in the circadian rhythms of Cynomolgus monkeys. Psychopharmacology 204 735 PMID: 19277609

If you know of a relevant reference for PF 670462, please let us know.

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关键词: PF 670462, PF 670462 supplier, Potent, selective, CK1ε, CK1epsilon, CK1δ, CK1delta, inhibitors, inhibits, Casein, Kinases, 1, PF670462, circadian, rhythms, Kinase, 3316, Tocris Bioscience