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PHT 427

Cat. No. 4598 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4598 has been discontinued.

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说明： Dual Akt and PDK1 inhibitor; antitumor
化学名： 4-Dodecyl-N-1,3,4-thiadiazol-2-yl-benzenesulfonamide
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for PHT 427

PHT 427 is a dual Akt and PDK1 inhibitor; binds the pleckstrin homology (PH) domain of Akt and PDK1 (Ki values are 2.7 and 5.2 μM, respectively). Inhibits Akt phosphorylation and Akt downstream targets; also induces apoptosis in vitro. Displays synergistic antitumor effect when combined with chemotherapeutics in breast cancer mouse models.

技术数据 for PHT 427

分子量 409.61
公式 C20H31N3O2S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1191951-57-1
PubChem ID 44240850
InChI Key BYWWNRBKPCPJMG-UHFFFAOYSA-N
Smiles O=S(C(C=C1)=CC=C1CCCCCCCCCCCC)(NC2=NN=CS2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for PHT 427

参考文献是支持产品生物活性的出版物。

Moses et al (2009) In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT. Cancer Res. 69 5073 PMID: 19491272

Meuillet et al (2010) Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol.Cancer Ther. 9 706 PMID: 20197390

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关键词: PHT 427, PHT 427 supplier, PHT427, Phosphatidylinositol, 3-kinase/phosphatidylinositide-dependent, protein, kinase, 1, PDPK1Akt,, pleckstrin, homology, PH, domain, AKT, inhibitors, inhibits, antitumor, duel, tumour, PDK1, Akt, (Protein, Kinase, B), Protein, B/Akt, Phosphoinositide-dependent, 4598, Tocris Bioscience

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Pathways for PHT 427

Akt Signaling Pathway

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.