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PND 1186

Cat. No. 6891 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent FAK inhibitor; orally bioavailable
化学名： 2-[[2-[[2-Methoxy-4-(4-morpholinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyridinyl]amino]-N-methylbenzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PND 1186

PND 1186 is a potent FAK inhibitor (IC50 values are 1.5 and 100 nM for recombinant FAK and FAK in breast carcinoma cells, respectively). Promotes caspase activation; triggering apoptosis. Inhibits 4T1 breast carcinoma subcutaneous tumor growth and breast carcinoma cell motility. Decreases spontaneous breast to lung metastasis in pre-clinical models. Orally bioavailable.

化合物库 for PND 1186

PND 1186 is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for PND 1186

分子量 501.51
公式 C25H26F3N5O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1061353-68-1
PubChem ID 25073775
InChI Key IGUBBWJDMLCRIK-UHFFFAOYSA-N
Smiles CNC(=O)C1=C(NC2=CC(NC3=C(OC)C=C(C=C3)N3CCOCC3)=NC=C2C(F)(F)F)C=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PND 1186

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 50.15 100

制备储备液 for PND 1186

以下数据基于产品分子量 501.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.99 mL 9.97 mL 19.94 mL
5 mM 0.4 mL 1.99 mL 3.99 mL
10 mM 0.2 mL 1 mL 1.99 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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参考文献 for PND 1186

参考文献是支持产品生物活性的出版物。

Walsh et al (2010) Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models. Cancer Biol.Ther. 9 778 PMID: 20234193

Tanjoni et al (2010) PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol.Ther. 9 764 PMID: 20234191

Jiang et al (2016) Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy. Nat.Med. 22 851 PMID: 27376576

If you know of a relevant reference for PND 1186, please let us know.

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关键词: PND 1186, PND 1186 supplier, PND1186, SR2516, VS4718, SR_2516, VS_4718, potent, FAK, inhibitors, inhibits, orally, bioavailable, caspase, activators, Focal, Adhesion, Kinase, 6891, Tocris Bioscience

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