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PP 121

Cat. No. 3894 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Dual kinase inhibitor; inhibits PI 3-K family kinases
化学名： 1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PP 121

PP 121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). Exhibits no significant effect on receptor serine/threonine kinases (RSTKs). Blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor.

化合物库 for PP 121

PP 121 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for PP 121

分子量 319.36
公式 C17H17N7
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1092788-83-4
PubChem ID 24905142
InChI Key NVRXTLZYXZNATH-UHFFFAOYSA-N
Smiles NC1=C2C(N(C5CCCC5)N=C2C3=CN=C(NC=C4)C4=C3)=NC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PP 121

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 31.94 100
ethanol 15.97 50

制备储备液 for PP 121

以下数据基于产品分子量 319.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.13 mL 15.66 mL 31.31 mL
5 mM 0.63 mL 3.13 mL 6.26 mL
10 mM 0.31 mL 1.57 mL 3.13 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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参考文献 for PP 121

参考文献是支持产品生物活性的出版物。

Apsel et al (2008) Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat.Chem.Biol. 4 691 PMID: 18849971

If you know of a relevant reference for PP 121, please let us know.

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关键词: PP 121, PP 121 supplier, PP121, PI, 3-K, 3-kinase, PI3K, dual, inhibitors, inhibits, receptor, tyrosine, kinases, RTKs, 3-Kinase, mTOR, Other, 3894, Tocris Bioscience

1 篇 PP 121 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PP 121 的部分引用包括：

So-Youn et al (2019) Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies. Cell Death Differ 26 502-515 PMID: 29988075

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