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PPY A

Cat. No. 4730 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent inhibitor of Abl T315l mutant and wild-type Abl kinases
化学名： 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethyl-3-pyridinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PPY A

PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinases (IC50 values are 9 and 20 nM, respectively). Inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene.

化合物库 for PPY A

PPY A is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for PPY A

分子量 372.42
公式 C22H20N4O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 875634-01-8
PubChem ID 16750094
InChI Key GYQRHHQPEMOLKH-UHFFFAOYSA-N
Smiles O=C(N(C)C)C1=CN=CC(C2=CN=C(NC=C3C4=C(OC)C=CC=C4)C3=C2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PPY A

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.24 100

制备储备液 for PPY A

以下数据基于产品分子量 372.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.43 mL 26.85 mL
5 mM 0.54 mL 2.69 mL 5.37 mL
10 mM 0.27 mL 1.34 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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产品说明书 for PPY A

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for PPY A

参考文献是支持产品生物活性的出版物。

Zhou et al (2007) Crystal structure of the T315I mutant of AbI kinase. Chem.Biol.Drug.Des. 70 171 PMID: 17718712

Noronha et al (2008) Inhibitors of ABL and the ABL-T315I mutation. Curr.Top.Med.Chem. 8 905 PMID: 18673174

If you know of a relevant reference for PPY A, please let us know.

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关键词: PPY A, PPY A supplier, PPYA, Bcr-Abl, BcrAbl, Bcr, Abl, fusion, tyrosine-kinase, inhibitors, inhibits, AblT315l, T315l, kinases, Kinase, 4730, Tocris Bioscience

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