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说明： PKC activator; also NF-κB activator
化学名： (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one
纯度： ≥98% (HPLC)
生物活性 for Prostratin
Prostratin is a PKC activator. Inhibits growth and induces differentiation of AML cell lines. Enhances cytarabine-induced differentiation of AML cells. Inhibits tumorigenesis in KRAS mutant pancreatic cancer cells and reduces tumor growth in mouse pancreatic tumor models. Also NF-κB activator. Activates HIV gene expression in T cells. Orally available.
技术数据 for Prostratin
| 分子量 | 390.47 |
| 公式 | C22H30O6 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 60857-08-1 |
| PubChem ID | 454217 |
| InChI Key | BOJKFRKNLSCGHY-HXGSDTCMSA-N |
| Smiles | OCC1=C[C@]([C@@](C2(C)C)([H])[C@@]2(OC(C)=O)C[C@H]3C)([H])[C@@]3(O)[C@@](C=C(C)C4=O)([H])[C@]4(O)C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Prostratin
参考文献 for Prostratin
参考文献是支持产品生物活性的出版物。
Shen et al (2015) The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents. Cancer Lett. 356 686 PMID: 25449427
Wang et al (2015) K-Ras promotes tumorigenicity through suppression of non-canonical Wnt signaling. Cell 163 1237 PMID: 26590425
Wang et al (2014) Protein kinase D3 is essential for prostratin-activated transcription of integrated HIV-1 provirus promoter via NF-κB signaling pathway. BioMed Res.Int. 2014 968027 PMID: 25136641
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关键词: Prostratin, Prostratin supplier, protein, kinase, C, activators, PKC, activation, NF-KB, Kappa, κ, differentiation, AML, orally, available, HIV, signaling, Protein, Kinase, NF-kB/IkB, 5739, Tocris Bioscience
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