PS 1145 dihydrochloride

Name: PS 1145 dihydrochloride
Brand: Tocris Bioscience
SKU: 4569

Cat. No. 4569 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4569 has been discontinued.

说明： Selective IKK inhibitor; orally active

化学名： N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (4)

生物活性技术数据说明书参考文献

生物活性 for PS 1145 dihydrochloride

PS 1145 dihydrochloride is a selective IκB kinase (IKK) inhibitor (IC₅₀ = 100 nM). Has no effect on PKA, PKC and CKII activity. Inhibits IκB-α phosphorylation and NFκB activation in HeLa cells. Inhibits NFκB-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF-α production in vivo. Orally active.

技术数据 for PS 1145 dihydrochloride

分子量	395.67
公式	C₁₇H₁₁ClN₄O.2HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1049743-58-9
PubChem ID	16219884
InChI Key	QTDCBADLGJZBHP-UHFFFAOYSA-N
Smiles	ClC1=CC(NC(C4=CC=CN=C4)=O)=C(NC3=C2C=CN=C3)C2=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for PS 1145 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PS 1145 dihydrochloride

参考文献是支持产品生物活性的出版物。

Castro et al (2003) Novel IKK inhibitors: beta-carbolines. Bioorg.Med.Chem.Lett. 13 2419 PMID: 12824047

Newton et al (2007) Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors. J.Pharmacol.Exp.Ther. 321 734 PMID: 17322026

Hideshima et al (2002) NF-kappa B as a therapeutic target in multiple myeloma. J.Biol.Chem. 277 16639 PMID: 11872748

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4 篇 PS 1145 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 PS 1145 dihydrochloride 的部分引用包括：

Gari et al (2016) Loss of the oncogenic phosphatase PRL-3 promotes a TNF-R1 feedback loop that mediates triple-negative breast cancer growth. Oncogenesis 5 e255 PMID: 27526109

Anastasia et al (2021) The cell polarity kinase Par1b/MARK2 activation selects specific NF-kB transcripts via phosphorylation of core mediator Med17/TRAP80. Mol Biol Cell 32 690-702 PMID: 33596087

Savas et al (2022) NF-κB memory coordinates transcriptional responses to dynamic inflammatory stimuli. Cell Rep 40 111159 PMID: 35977475

L Gail et al (2022) Induction of IDO1 and Kynurenine by Serine Proteases Subtilisin, Prostate Specific Antigen, CD26 and HtrA: A New Form of Immunosuppression? Front Immunol 13 832989 PMID: 35371018