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Submit ReviewPS 48
Discontinued Product
4087 has been discontinued.
View all Phosphoinositide-dependent Kinase 1 products.
说明： PDK1 activator
化学名： (2Z)-5-(4-Chlorophenyl)-3-phenyl-2-pentenoic acid
纯度： ≥98% (HPLC)
生物活性 for PS 48
Phosphoinositide-dependent protein kinase-1 (PDK1) activator (Kd = 10.3 μM). Binds exclusively to the PIF-binding pocket of PDK1, distinct from the ATP binding site.
技术数据 for PS 48
| 分子量 | 286.75 |
| 公式 | C17H15ClO2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1180676-32-7 |
| Smiles | ClC1=CC=C(CC/C(C2=CC=CC=C2)=C/C(O)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PS 48
参考文献 for PS 48
参考文献是支持产品生物活性的出版物。
Hindie et al (2009) Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat.Chem.Biol. 5 758 PMID: 19718043
Stroba et al (2009) 3,5-diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds. J.Med.Chem. 52 4683 PMID: 19606904
Williams (2010) Elastic network model of allosteric regulation in protein kinase PDK1. BMC Struct.Biol. 10 11 PMID: 20500829
Zhu et al (2010) Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell. 7 651 PMID: 21112560
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关键词: PS 48, PS 48 supplier, phosphoinositide-dependent, protein, kinase, 1, pdk1, activators, allosteric, PS48, Phosphoinositide-dependent, Kinase, PDK1, Enzyme, Substrates, /, Activators, 4087, Tocris Bioscience
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