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Submit ReviewPTC 209
说明： Bmi-1 inhibitor; antitumor
化学名： N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine
纯度： ≥98% (HPLC)
生物活性 for PTC 209
PTC 209 is a Bmi-1 inhibitor (IC50 ~ 0.5 μM); irreversibly impairs colorectal cancer-initiating cell (CIC) growth. Reduces tumor growth in CIC xenograft assays and results in reduced potential of colorectal cancer cells to initiate tumors in vivo.
技术数据 for PTC 209
| 分子量 | 495.19 |
| 公式 | C17H13Br2N5OS |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 315704-66-6 |
| PubChem ID | 1117196 |
| InChI Key | XVOOCQSWCCRVDY-UHFFFAOYSA-N |
| Smiles | CC3=C(N(C=CC=N4)C4=N3)C1=CSC(NC2=C(Br)C=C(OC)C=C2Br)=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PTC 209
参考文献 for PTC 209
参考文献是支持产品生物活性的出版物。
Kreso et al (2014) Self-renewal as a therapeutic target in human colorectal cancer. Nat.Med. 20 29 PMID: 24292392
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关键词: PTC 209, PTC 209 supplier, PTC209, Bmi-1, inhibitors, inhibits, colorectal, cancer-initiating, cell, CIC, growth, polycomb, repressive, complex, 1, PRC1, B, lymphoma, Mo-MLV, insertion, region, homolog, Ubiquitin, E3, Ligases, 5191, Tocris Bioscience
2 篇 PTC 209 的引用文献
引用文献是使用了 Tocris 产品的出版物。 PTC 209 的部分引用包括：
Zhaocheng et al (2021) Inverse and reciprocal regulation of p53/p21 and Bmi-1 modulates vasculogenic differentiation of dental pulp stem cells. Cell Death Dis 12 644 PMID: 34168122
Yan et al (2019) The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression. Cancer Cell 36 139-155.e10 PMID: 31327655
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
TPD and Induced Proximity Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Assays for Protein Degradation
- Induced Proximity Tools
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia