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PZ 3022

Cat. No. 7876 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： PanK Activator
化学名： 6-[4-[2-(4-Cyclopropylphenyl)acetyl]-1-piperazinyl]-3-pyridazinecarbonitrile
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for PZ 3022

PZ 3022 is a potent allosteric pantothenate kinase (PanK) activator (EC50=5.3 nM for PanK3). In a mouse model of propionic acidemia, treatment with PZ 3022 increases hepatic CoASH and C2-CoA, and decreases C3-CoA, improving intracellular C3:C2-CoA ratio and plasma C3:C2-carnitine ratios. PZ 3022 is orally bioavailable.

许可信息

Sold under license from St. Jude Children's Research Hospital

技术数据 for PZ 3022

分子量 347.42
公式 C20H21N5O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2170608-85-0
PubChem ID 132261124
InChI Key CXSADKGUEBUMLH-UHFFFAOYSA-N
Smiles N#CC1=NN=C(N2CCN(CC2)C(CC3=CC=C(C4CC4)C=C3)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PZ 3022

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 34.74 100

制备储备液 for PZ 3022

以下数据基于产品分子量 347.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.88 mL 14.39 mL 28.78 mL
5 mM 0.58 mL 2.88 mL 5.76 mL
10 mM 0.29 mL 1.44 mL 2.88 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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参考文献 for PZ 3022

参考文献是支持产品生物活性的出版物。

Subramanian et al (2021) Pantothenate kinase activation relieves coenzyme A sequestration and improves mitochondrial function in mice with propionic acidemia. Sci.Transl.Med. 13 eabf5965 PMID: 34524863

If you know of a relevant reference for PZ 3022, please let us know.

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关键词: PZ 3022, PZ 3022 supplier, PZ3022, orally, bioavailable, in, vivo, PZ-3022, hepatic, CoASH, C2-CoA, C3-CoA, C3:C2-CoA, C3:C2-carnitine, carnitine, TCA, cycle, Other, Kinases, 7876, Tocris Bioscience

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