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Quercetin

Cat. No. 1125 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Non-selective PI 3-kinase inhibitor
化学名： 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Quercetin

Quercetin is an antitumor agent; induces apoptosis and inhibits synthesis of heat shock proteins. Inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Can also activate Ca2+ and K+ channels and behaves as an agonist at estrogen (GPER) receptors. Blocks cellular entry by influenza A virus via an interaction with hemaglutinin. Inhibits SARS-CoV 3CLpro (IC50 = 73 μM). Targets and eliminates senescent cells. Orally bioavailable.

技术数据 for Quercetin

分子量 302.24
公式 C15H10O7
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 117-39-5
PubChem ID 5280343
InChI Key REFJWTPEDVJJIY-UHFFFAOYSA-N
Smiles OC1=CC(O)=C2C(OC(=C(O)C2=O)C2=CC=C(O)C(O)=C2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Quercetin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 100

制备储备液 for Quercetin

以下数据基于产品分子量 302.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.31 mL 16.54 mL 33.09 mL
5 mM 0.66 mL 3.31 mL 6.62 mL
10 mM 0.33 mL 1.65 mL 3.31 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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参考文献 for Quercetin

参考文献是支持产品生物活性的出版物。

Cermak et al (2002) The flavonol quercetin activates basolateral K+ channels in rat distal colon epithelium. Br.J.Pharmacol. 135 1183 PMID: 11877325

Graziani et al (1983) The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo. J.Biochem. 135 583 PMID: 6311542

Levy et al (1984) Tyrosine protein kinase activity in the DMBA-induced rat mammary tumor: inhibition by quercetin. Biochem.Biophys.Res.Commun. 123 1227 PMID: 6091650

Saponara et al (2002) Quercetin as a novel activator of L-type Ca2+ channels in rat tail artery smooth muscle cells. Br.J.Pharmacol. 135 1819 PMID: 11934824

Wei et al (1994) Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res. 54 4952 PMID: 8069862

Wu et al (2015) Quercetin as an antiviral agent inhibits influenza A virus (IAV) entry. Viruses 8 6 PMID: 26712783

Nguyen et al (2012) Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris. Biotechnol.Lett. 34 831 PMID: 22350287

If you know of a relevant reference for Quercetin, please let us know.

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关键词: Quercetin, Quercetin supplier, Non-Selective, PI, 3-kinase, inhibitors, inhibits, GPR30, agonists, non-selective, 3-Kinase, PI3K, Akt, Signaling, Signalling, PIP2, Inositol, Lipids, cAMP, Receptors, Estrogen, receptors, Phosphoinositide, Kinases, GPER, antiviral, influenza, virus, SARS-Cov, coronavirus, 3CLpro, (GPER), IRE1, COVID-19, 3C, and, 3CL, Proteases, Influenza, Viruses, Coronavirus, 1125, Tocris Bioscience

3 篇 Quercetin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Quercetin 的部分引用包括：

Yao et al (2016) Clobetasol promotes remyelination in a mouse model of neuromyelitis optica. Acta Neuropathol Commun 4 42 PMID: 27117475

Rees et al (2016) Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Neurochem Int 12 109 PMID: 26656090

Filone et al (2014) The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection. PLoS Pathog 10 e1003904 PMID: 24516381

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