主页 / 药理学 / Enzymes / Kinases / Diacylglycerol Kinases / Diacylglycerol Kinase Inhibitors / R 59-022

R 59-022

Cat. No. 2194 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2194 has been discontinued.

View all Diacylglycerol Kinases products.
说明： Diacylglycerol kinase inhibitor; increases PKC activity
化学名： 6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for R 59-022

R 59-022 is a diacylglycerol (DAG) kinase inhibitor (IC50 = 2.8 μM); increases protein kinase C activity. Potentiates thrombin-induced platelet aggregation and induces neutrophil chemotaxis. Inhibits U46619-induced contractions in mouse aorta and porcine coronary artery.

技术数据 for R 59-022

分子量 459.58
公式 C27H26FN3OS
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 93076-89-2
PubChem ID 3012
InChI Key MFVJXLPANKSLLD-UHFFFAOYSA-N
Smiles CC1=C(CCN2CC\C(CC2)=C(/C2=CC=CC=C2)C2=CC=C(F)C=C2)C(=O)N2C=CSC2=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for R 59-022

参考文献是支持产品生物活性的出版物。

de Chaffoy de Courcelles et al (1985) R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet. J.Biol.Chem. 260 15762 PMID: 2999135

Nunn and Watson (1987) A diacylglyerol kinase inhibitor, R59022, potentiates secretion by and aggregation of thrombin-stimulated human platelets. Biochem.J. 243 809 PMID: 2821994

Boonen et al (1993) Neutrophil chemotaxis induced by the diacylglycerol kinase inhibitor R59022. Biochim.Biophys.Acta 1178 97 PMID: 8392381

Nobe et al (2004) Novel diacylglycerol kinase inhibitor selectively suppressed an U46619-induced enhancement of mouse portal vein contraction under high glucose conditions. Br.J.Pharmacol. 143 166 PMID: 15289283

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Diacylglycerol Kinase Inhibitors

关键词: R 59-022, R 59-022 supplier, Diacylglycerol, kinase, inhibitors, inhibits, increases, PKC, activity, DGK, DAG, Kinase, Kinases, Lipid, Metabolism, R59022, 2194, Tocris Bioscience

1 篇 R 59-022 的引用文献

引用文献是使用了 Tocris 产品的出版物。 R 59-022 的部分引用包括：

Conley et al (2015) Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti. Nature 352 53 PMID: 25332454

R 59-022 的评论

目前没有该产品的评论。 Be the first to review R 59-022 and earn rewards!

Have you used R 59-022?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review