(R)-DRF053 dihydrochloride

Pricing Availability   Qty
说明: Potent CK1 inhibitor; also inhibits cyclin-dependent kinases
化学名: 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanol dihydrochloride
纯度: ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)

生物活性 for (R)-DRF053 dihydrochloride

(R)-DRF053 dihydrochloride is a potent casein kinase 1 (CK1) inhibitor (IC50 = 14 nM). Also an ATP-competitive cyclin-dependent kinase (cdk) inhibitor (IC50 values are 0.093 - 0.29, 0.21 and 0.82 μM for cdk2, cdk5 and cdk7, respectively). Shown to inhibit amyloid-β production in N2A-APP695 cells.

化合物库 for (R)-DRF053 dihydrochloride

(R)-DRF053 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for (R)-DRF053 dihydrochloride

分子量 490.43
公式 C23H27N7O.2HCl
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1241675-76-2
PubChem ID 71433624
InChI Key BQPRBNGSDBTKAK-ZEECNFPPSA-N
Smiles CC(C)N2C1=NC(N[C@H](CC)CO)=NC(NC3=CC(C4=NC=CC=C4)=CC=C3)=C1N=C2.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (R)-DRF053 dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 49.04 100
DMSO 49.04 100

制备储备液 for (R)-DRF053 dihydrochloride

以下数据基于产品分子量 490.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.2 mL 20.39 mL
5 mM 0.41 mL 2.04 mL 4.08 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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产品说明书 for (R)-DRF053 dihydrochloride

分析证书/产品说明书
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参考文献 for (R)-DRF053 dihydrochloride

参考文献是支持产品生物活性的出版物。

Oumata et al (2008) Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. J.Med.Chem. 51 522

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987


If you know of a relevant reference for (R)-DRF053 dihydrochloride, please let us know.

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查看全部 Casein Kinase 1 Inhibitors

关键词: (R)-DRF053 dihydrochloride, (R)-DRF053 dihydrochloride supplier, casein, cyclin-dependent, kinases, cyclin, cdk5, cdk1, CK1, p25, dual, specificity, inhibits, inhibitors, Casein, Kinase, 1, Cyclin-dependent, Non-selective, CDKs, 3610, Tocris Bioscience

1 篇 (R)-DRF053 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (R)-DRF053 dihydrochloride 的部分引用包括:

Goonesekere et al (2014) A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers. PLoS One 9 e93046 PMID: 24740004


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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

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