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Submit Review(R)-DRF053 dihydrochloride is a potent casein kinase 1 (CK1) inhibitor (IC50 = 14 nM). Also an ATP-competitive cyclin-dependent kinase (cdk) inhibitor (IC50 values are 0.093 - 0.29, 0.21 and 0.82 μM for cdk2, cdk5 and cdk7, respectively). Shown to inhibit amyloid-β production in N2A-APP695 cells.
(R)-DRF053 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。
分子量 | 490.43 |
公式 | C23H27N7O.2HCl |
储存 | Store at +4°C |
纯度 | ≥98% (HPLC) |
CAS Number | 1241675-76-2 |
PubChem ID | 71433624 |
InChI Key | BQPRBNGSDBTKAK-ZEECNFPPSA-N |
Smiles | CC(C)N2C1=NC(N[C@H](CC)CO)=NC(NC3=CC(C4=NC=CC=C4)=CC=C3)=C1N=C2.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
water | 49.04 | 100 | |
DMSO | 49.04 | 100 |
以下数据基于产品分子量 490.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.04 mL | 10.2 mL | 20.39 mL |
5 mM | 0.41 mL | 2.04 mL | 4.08 mL |
10 mM | 0.2 mL | 1.02 mL | 2.04 mL |
50 mM | 0.04 mL | 0.2 mL | 0.41 mL |
参考文献是支持产品生物活性的出版物。
Oumata et al (2008) Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. J.Med.Chem. 51 522
Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987
If you know of a relevant reference for (R)-DRF053 dihydrochloride, please let us know.
关键词: (R)-DRF053 dihydrochloride, (R)-DRF053 dihydrochloride supplier, casein, cyclin-dependent, kinases, cyclin, cdk5, cdk1, CK1, p25, dual, specificity, inhibits, inhibitors, Casein, Kinase, 1, Cyclin-dependent, Non-selective, CDKs, 3610, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 (R)-DRF053 dihydrochloride 的部分引用包括:
Goonesekere et al (2014) A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers. PLoS One 9 e93046 PMID: 24740004
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This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for: