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RITA

Cat. No. 2443 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： MDM2-p53 interaction inhibitor
别名： NSC 652287
化学名： 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol
纯度： ≥97% (HPLC)
说明书
引用文献 (1)
评论
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for RITA

RITA is an anti-tumor agent that binds wild-type p53 (Kd = 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing wild-type p53 in vitro and in vivo. Inhibits HPV-E6-mediated proteasomal degradation. Suppresses expression of cervical carcinoma HeLa xenografts in vivo.

技术数据 for RITA

分子量 292.37
公式 C14H12O3S2
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 213261-59-7
PubChem ID 374536
InChI Key KZENBFUSKMWCJF-UHFFFAOYSA-N
Smiles OCC1=CC=C(S1)C1=CC=C(O1)C1=CC=C(CO)S1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RITA

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.23 100
ethanol 7.31 25

制备储备液 for RITA

以下数据基于产品分子量 292.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.42 mL 17.1 mL 34.2 mL
5 mM 0.68 mL 3.42 mL 6.84 mL
10 mM 0.34 mL 1.71 mL 3.42 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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产品说明书 for RITA

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for RITA

参考文献是支持产品生物活性的出版物。

Rivera et al (1999) Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism. Biochem.Pharmacol. 57 1283 PMID: 10230772

Zhao et al (2010) Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer Res. 70 3372 PMID: 20395210

Issaeva et al (2004) Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumours. Nature Med. 10 1321

Espinoza-Fonseca (2005) Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer. Theor.Biol.Med.Mod. 2 38

If you know of a relevant reference for RITA, please let us know.

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关键词: RITA, RITA supplier, p53-MDM2, interaction, inhibitors, inhibits, antitumor, agent, MDM2-p53, MDM2, p14ARF, p53, Ligases, Transcription, Factors, NSC652287, NSC, 652287, Ubiquitin, E3, 2443, Tocris Bioscience

1 篇 RITA 的引用文献

引用文献是使用了 Tocris 产品的出版物。 RITA 的部分引用包括：

Thotala et al (2012) Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway. Cell Death Differ 19 387 PMID: 21738215

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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