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SB 24011

Cat. No. 8010 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibitor of STING-TRIM29 interaction; increases cellular STING levels
化学名： 4-[(2R)-3,4-Dihydro-4-[(4-hydroxyphenyl)methyl]-5-[(4-methoxyphenyl)methyl]-2-(1-methylethyl)-3-oxo-1(2H)-pyrazinyl]-3-nitro-N-[[(2S)-tetrahydro-2-furanyl]methyl]benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SB 24011

SB 24011 is an inhibitor of STING-TRIM29 interaction (IC50 = 3.85 μM in vitro). SB 24011 binds to STING and inhibits TRIM29-E3 ligase interaction to increase cellular STING levels. In syngeneic mouse models, SB 24011 dose-dependently reduces CT26 and B16F10 tumor volumes when co-admistered with cGAMP.

技术数据 for SB 24011

分子量 614.7
公式 C34H38N4O7
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1497415-41-4
PubChem ID 171038176
InChI Key UZVHJOMTRTYDKL-BHDXBOSCSA-N
Smiles CC([C@H]1N(C2=C(C=C(C=C2)C(NC[C@@H]3CCCO3)=O)[N+]([O-])=O)C=C(N(C1=O)CC4=CC=C(C=C4)O)CC5=CC=C(C=C5)OC)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SB 24011

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 61.47 100

制备储备液 for SB 24011

以下数据基于产品分子量 614.7。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.63 mL 8.13 mL 16.27 mL
5 mM 0.33 mL 1.63 mL 3.25 mL
10 mM 0.16 mL 0.81 mL 1.63 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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参考文献 for SB 24011

参考文献是支持产品生物活性的出版物。

Cho et al (2023) Targeted protein upregulation of STING for boosting the efficacy of immunotherapy. Angew.Chem.Int.Ed.Engl. 62 e202300978 PMID: 36827625

If you know of a relevant reference for SB 24011, please let us know.

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关键词: SB 24011, SB 24011 supplier, SB24011, STING, TRIM29, inhibitors, inhibits, interaction, protein, dimer, dimerization, upregulation, upregulates, E3, ligase, Protein, Dimerizers, 8010, Tocris Bioscience

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