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SB 772077B dihydrochloride

Cat. No. 4118 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent Rho-kinase inhibitor; vasodilator
化学名： (3S)-1-[[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-7-yl]carbonyl]-3-pyrrolidinamine dihydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SB 772077B dihydrochloride

SB 772077B dihydrochloride is a potent Rho-kinase (ROCK) inhibitor (IC50 value of approximately 5.6 nM at recombinant human ROCK1 and 2). Decreases pulmonary and systemic arterial blood pressures and increases cardiac output. Exhibits vasodilator activity that is more potent than Y-27632 (Cat. No 1254) or Fasudil (Cat. No. 0541).

许可信息

Sold for research purposes under agreement from GlaxoSmithKline

化合物库 for SB 772077B dihydrochloride

SB 772077B dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for SB 772077B dihydrochloride

分子量 415.28
公式 C15H18N8O2.2HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 607373-46-6
PubChem ID 69157798
InChI Key HSROPTGRSYJPJY-JZGIKJSDSA-N
Smiles NC1=NON=C1C3=NC2=CN=CC(C(N4CC[C@H](N)C4)=O)=C2N3CC.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SB 772077B dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 41.53 100
DMSO 41.53 100

制备储备液 for SB 772077B dihydrochloride

以下数据基于产品分子量 415.28。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.04 mL 24.08 mL
5 mM 0.48 mL 2.41 mL 4.82 mL
10 mM 0.24 mL 1.2 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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产品说明书 for SB 772077B dihydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for SB 772077B dihydrochloride

参考文献是支持产品生物活性的出版物。

Doe et al (2007) Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J.Pharmacol.Exp.Ther. 320 89 PMID: 17018693

Dhaliwal et al (2009) Analysis of pulmonary vasodilator responses to SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitor. J.Pharm.Exp.Ther. 330 334

If you know of a relevant reference for SB 772077B dihydrochloride, please let us know.

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关键词: SB 772077B dihydrochloride, SB 772077B dihydrochloride supplier, SB772077B, 2HCl, Rho, Kinase, inhibitors, inhibits, ROCK, anti-inflammatory, vasodilators, antihypertensive, Rho-kinases, 4118, Tocris Bioscience

1 篇 SB 772077B dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SB 772077B dihydrochloride 的部分引用包括：

Lotz-Jenne et al (2016) A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor. Oncotarget 7 25983 PMID: 27036020

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