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SBE 13 hydrochloride

Cat. No. 4292 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4292 has been discontinued.

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说明： Potent and selective PLK1 inhibitor
化学名： N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxybenzeneethanamine hydrochloride
纯度： ≥99% (HPLC)
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引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for SBE 13 hydrochloride

Selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μM for PLK1, PLK3 and PLK2 respectively). Exhibits no effect on Aurora kinase A activity. Binds and stabilizes the inactive form of PLK1. Delays cell cycle progression, reduces cell proliferation and induces apoptosis in a range of human cancer cell lines. Transiently arrests cells cycle at G0/G1 in primary cells.

技术数据 for SBE 13 hydrochloride

分子量 479.4
公式 C24H27ClN2O4.HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 1052532-15-6
PubChem ID 11948807
InChI Key QBGSVDJLQQXEGG-UHFFFAOYSA-N
Smiles ClC(N=C3)=CC=C3COC1=C(OC)C=C(CNCCC2=CC(OC)=C(OC)C=C2)C=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for SBE 13 hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for SBE 13 hydrochloride

参考文献是支持产品生物活性的出版物。

Eckerdt (2010) Freezing Polo in its sleep: targeting the inactive conformation of Polo-like kinase 1 in cancer cells. Cell Cycle 9 862 PMID: 20348843

Keppner et al (2010) Biological impact of freezing Plk1 in its inactive conformation in cancer cells. Cell Cycle 9 761 PMID: 20139717

Liu (2010) SBE13 joins the family of Polo-like kinase 1 (Plk1) inhibitors. Cell Cycle 9 445 PMID: 20130451

Keppner et al (2011) Fate of primary cells at the G1/S boundary after Polo-like kinase 1 inhibition by SBE13. Cell Cycle 10 708 PMID: 21301227

Keppner et al (2009) Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1. ChemMedChem 4 1806 PMID: 19746360

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关键词: SBE 13 hydrochloride, SBE 13 hydrochloride supplier, SBE13, polo-like, kinases, plk1, plk, selective, potent, Polo-like, Kinase, Mitosis, 4292, Tocris Bioscience

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