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SC 66

Cat. No. 4398 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4398 has been discontinued.

View all Akt (Protein Kinase B) products.
说明： Allosteric Akt inhibitor
化学名： (2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论 (1)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for SC 66

SC 66 is an allosteric inhibitor of Akt; interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Exhibits anticancer activity in vitro and in vivo.

技术数据 for SC 66

分子量 276.33
公式 C18H16N2O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 871361-88-5
PubChem ID 6018993
InChI Key CYVVJSKZRBZHAV-UNZYHPAISA-N
Smiles O=C(/C(CCC3)=C/C2=CC=NC=C2)/C3=C/C1=CC=NC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for SC 66

参考文献是支持产品生物活性的出版物。

Jo et al (2011) Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc.Natl.Acad.Sci.USA 108 6486 PMID: 21464312

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关键词: SC 66, SC 66 supplier, SC66, akt, pkb, protein, kinase, b, inhibitors, inhibits, allosteric, dual, activity, inhibitory, Akt, (Protein, Kinase, B), Protein, B/Akt, 4398, Tocris Bioscience

2 篇 SC 66 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SC 66 的部分引用包括：

Deng et al (2018) HPV16-Immortalized Cells from Human Transformation Zone and Endocervix are More Dysplastic than Ectocervical Cells in Organotypic Culture. Sci Rep 8 15402 PMID: 30337615

Hung et al (2015) p22phox confers resistance to cisplatin, by blocking its entry into the nucleus. J Cell Biol 6 4110 PMID: 25686830

SC 66 的评论

平均评分: 5 (Based on 1 Review.)

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SC 66 inhibits LPA induced COX-2 in osteosarcoma cells.
By Christopher Trummer on 10/23/2018
分析类型： In Vitro
种属： Human
细胞系/组织： Osteosarcoma

MG-63 cells were treated with LPA (10 µM) alone or in the presence of SC 66 (0-10 µM) for 3 h to follow COX-2 expression using Western blot. SC 66 inhibited LPA-induced COX-2 expression in a concentration dependent manner starting from 5 µM.

review image

Pathways for SC 66

Akt Signaling Pathway

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.