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SC 79

Cat. No. 4635 11 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Akt activator
化学名： 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester
说明书
引用文献 (11)
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SC 79

SC 79 is an activator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.

技术数据 for SC 79

分子量 364.78
公式 C17H17ClN2O5
储存 Store at -20°C
CAS Number 305834-79-1
PubChem ID 2810830
InChI Key DXVKFBGVVRSOLI-UHFFFAOYSA-N
Smiles NC2=C(C(OCC)=O)C(C(C(OCC)=O)C#N)C1=CC(Cl)=CC=C1O2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SC 79

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.48 100

制备储备液 for SC 79

以下数据基于产品分子量 364.78。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.71 mL 27.41 mL
5 mM 0.55 mL 2.74 mL 5.48 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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参考文献 for SC 79

参考文献是支持产品生物活性的出版物。

Jo et al (2012) Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc.Natl.Acad.Sci.USA 109 10581 PMID: 22689977

If you know of a relevant reference for SC 79, please let us know.

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关键词: SC 79, SC 79 supplier, SC79, Akt, protein, kinase, B, PKB, activators, activates, brain, penetrant, (Protein, Kinase, B), Protein, B/Akt, 4635, Tocris Bioscience

11 篇 SC 79 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SC 79 的部分引用包括：

Moreira et al (2015) A small molecule activator of AKT does not reduce ischemic injury of the rat heart. J Transl Med 13 76 PMID: 25889299

Bei et al (2016) miR-382 targeting PTEN-Akt axis promotes liver regeneration. Mol Syst Biol 7 1584 PMID: 26636539

Yutao et al (2021) FGF20-FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti. Dev Dyn 250 134-144 PMID: 32735383

Lucie et al (2022) Regulation of Stress-Activated Kinases in Response to Tacaribe Virus Infection and Its Implications for Viral Replication. Viruses 14 PMID: 36146824

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Pathways for SC 79

Akt Signaling Pathway

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.