主页 / 细胞生物学 / Signal Transduction / Cytokine and NF-κB Signaling / STATs / STAT Inhibitors / SD 1008

SD 1008

Cat. No. 3035 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： JAK2/STAT3 signaling pathway inhibitor
化学名： (1R,5R,6R,7S)-rel-4-Oxo-8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid 6,7-dimethyl ester
纯度： ≥99% (HPLC)
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SD 1008

SD 1008 is a JAK2/STAT3 signaling pathway inhibitor. Inhibits activation of STAT3, JAK2 and Src. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

化合物库 for SD 1008

SD 1008 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for SD 1008

分子量 329.35
公式 C18H19NO5
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 960201-81-4
PubChem ID 90488795
InChI Key XJLVVXLRQMISCS-ROINDZCWSA-N
Smiles O=C1C=C[C@@H]2[C@@H]([C@](OC)=O)[C@@H]([C@](OC)=O)[C@H]1N2CC3=CC=CC=C3.O=C4C=C[C@H]5[C@H](C(OC)=O)[C@H](C(OC)=O)[C@@H]4N5CC6=CC=CC=C6

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SD 1008

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 32.94 100
ethanol 1.65 5

制备储备液 for SD 1008

以下数据基于产品分子量 329.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.04 mL 15.18 mL 30.36 mL
5 mM 0.61 mL 3.04 mL 6.07 mL
10 mM 0.3 mL 1.52 mL 3.04 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for SD 1008

参考文献是支持产品生物活性的出版物。

Duan et al (2007) 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel Janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells. Mol.Pharmacol. 72 1137 PMID: 17675586

If you know of a relevant reference for SD 1008, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 STAT Inhibitors

关键词: SD 1008, SD 1008 supplier, JAK2, STAT3, signaling, pathway, inhibitors, inhibits, activation, Src, SD1008, STAT, JAK, Kinase, 3035, Tocris Bioscience

篇 SD 1008 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 SD 1008 的引用文献。 您是否知道使用了 Tocris SD 1008 的优秀论文？ 请告知我们.

SD 1008 的评论

目前没有该产品的评论。 Be the first to review SD 1008 and earn rewards!

Have you used SD 1008?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Pathways for SD 1008

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.