SKI II

Cat. No. 2097 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2097 has been discontinued.

View all Sphingosine Kinase products.

说明： Selective non-lipid inhibitor of sphingosine kinase

化学名： 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol

纯度： ≥98% (HPLC)

说明书

引用文献 (6)

生物活性技术数据说明书参考文献

生物活性 for SKI II

SKI II is a selective non-lipid inhibitor of sphingosine kinase (IC₅₀ = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC₅₀ = 0.9 - 4.6 μM).

技术数据 for SKI II

分子量	302.78
公式	C₁₅H₁₁ClN₂OS
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	312636-16-1
PubChem ID	753704
InChI Key	ZFGXZJKLOFCECI-UHFFFAOYSA-N
Smiles	OC1=CC=C(NC2=NC(=CS2)C2=CC=C(Cl)C=C2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for SKI II

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SKI II

参考文献是支持产品生物活性的出版物。

French et al (2006) Antitumor activity of sphingosine kinase inhibitors. J.Pharmacol.Exp.Ther. 318 596 PMID: 16632640

French et al (2003) Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 63 5862

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关键词: SKI II, SKI II supplier, Selective, non-lipid, inhibitors, inhibits, sphingosine, kinases, antitumor, Lipid, Metabolism, sphingosine-1-phosphate, S1P, SKIII, sphk, Sphingosine, Kinase, 2097, Tocris Bioscience