SKI II

Cat. No. 2097 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective non-lipid inhibitor of sphingosine kinase

化学名： 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol

纯度： ≥98% (HPLC)

说明书

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SKI II

SKI II is a selective non-lipid inhibitor of sphingosine kinase (IC₅₀ = 0.5 μM); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC₅₀ = 0.9 - 4.6 μM).

技术数据 for SKI II

分子量	302.78
公式	C₁₅H₁₁ClN₂OS
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	312636-16-1
PubChem ID	753704
InChI Key	ZFGXZJKLOFCECI-UHFFFAOYSA-N
Smiles	OC1=CC=C(NC2=NC(=CS2)C2=CC=C(Cl)C=C2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SKI II

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	30.28	100

制备储备液 for SKI II

以下数据基于产品分子量 302.78。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.3 mL	16.51 mL	33.03 mL
5 mM	0.66 mL	3.3 mL	6.61 mL
10 mM	0.33 mL	1.65 mL	3.3 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

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产品说明书 for SKI II

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SKI II

参考文献是支持产品生物活性的出版物。

French et al (2006) Antitumor activity of sphingosine kinase inhibitors. J.Pharmacol.Exp.Ther. 318 596 PMID: 16632640

French et al (2003) Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 63 5862

If you know of a relevant reference for SKI II, please let us know.

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关键词: SKI II, SKI II supplier, Selective, non-lipid, inhibitors, inhibits, sphingosine, kinases, antitumor, Lipid, Metabolism, sphingosine-1-phosphate, S1P, SKIII, sphk, Sphingosine, Kinase, 2097, Tocris Bioscience