SL 327

Cat. No. 1969 20 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective inhibitor of MEK1 and MEK2; brain penetrant

化学名： α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile

纯度： ≥99% (HPLC)

说明书

引用文献 (20)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SL 327

SL 327 is a selective inhibitor of MEK1 and MEK2 (IC₅₀ values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.

技术数据 for SL 327

分子量	335.35
公式	C₁₆H₁₂F₃N₃S
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	305350-87-2
PubChem ID	9549284
InChI Key	JLOXTZFYJNCPIS-FYWRMAATSA-N
Smiles	N\C(SC1=CC=C(N)C=C1)=C(\C#N)C1=CC=CC=C1C(F)(F)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SL 327

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	16.77	50
	DMSO	33.53	100

制备储备液 for SL 327

以下数据基于产品分子量 335.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.98 mL	14.91 mL	29.82 mL
5 mM	0.6 mL	2.98 mL	5.96 mL
10 mM	0.3 mL	1.49 mL	2.98 mL
50 mM	0.06 mL	0.3 mL	0.6 mL

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产品说明书 for SL 327

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SL 327

参考文献是支持产品生物活性的出版物。

Davis et al (2000) The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo. J.Neurosci. 20 4563 PMID: 10844026

Scherle et al (2000) Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy. J.Biol.Chem. 275 37086 PMID: 10969080

Wang et al (2003) Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. J.Pharmacol.Exp.Ther. 304 172 PMID: 12490588

Atkins et al (1998) The MAPK cascade is required for mammalian associative learning. Nature Neurosci. 1 602 PMID: 10196568

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关键词: SL 327, SL 327 supplier, Selective, inhibitors, inhibits, MEK1, MEK2, brain, penetrant, Mitogen-Activated, Protein, Kinase, MEK, Kinases, SL327, 1969, Tocris Bioscience

20 篇 SL 327 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SL 327 的部分引用包括：

Alter et al (2010) Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models. J Neurosci 30 11537 PMID: 20739576

Osterweil et al (2010) Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome. J Neurosci 30 15616 PMID: 21084617

Liddell et al (2016) Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. J Neuroinflammation 13 49 PMID: 26920699

Rhim et al (2016) Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells Scientific Reports 6 26547 PMID: 27211495

Urs et al (2015) Targeting β-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease. J Biol Chem 112 E2517 PMID: 25918399

Lee et al (2014) Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome. Nat Neurosci 17 1736 PMID: 25383899

Seese et al (2014) Spaced training rescues memory and ERK1/2 signaling in fragile X syndrome model mice. Proc Natl Acad Sci U S A 111 16907 PMID: 25385607

Evron et al (2014) G Protein and β-arrestin signaling bias at the ghrelin receptor. J Biol Chem 289 33442 PMID: 25261469

Oh et al (2017) Negative regulation of ERK1/2 by PI3K is required for the protective effects of Pyropia yezoensis peptide against perfluorooctane sulfonate-induced endoplasmic reticulum stress. Mol Med Rep 15 2583 PMID: 28260037

Kubota et al (2014) mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS One 9 e106316 PMID: 25181481

Freeman et al (2011) A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death. Cancer Biol Ther 12 966 PMID: 22108021

Urs et al (2011) A DA D1 receptor-dependent β-arrestin signaling complex potentially regulates morphine-induced psychomotor activation but not reward in mice. Neuropsychopharmacology 36 551 PMID: 20980993

Subramanian and Morozov (2011) Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels. J Neurosci 31 4755 PMID: 21430174

Zakharova et al (2019) The Protective Effect of Ins. on Rat Cortical Neurons in Oxidative Stress and Its Dependence on the Modulation of Akt, GSK-3beta, ERK1/2, and AMPK Activities. Int J Mol Sci 20 PMID: 31362343

Keasey et al (2013) Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal 11 35 PMID: 23693126

Faccidomo et al (2009) Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK1/2, but not JNK, MAP kinase pathway. Psychopharmacology (Berl) 204 135 PMID: 19125235

Chen-Roetling et al (2009) Heme oxygenase activity and hemoglobin neurotoxicity are attenuated by inhibitors of the MEK/ERK pathway. Neuropharmacology 56 922 PMID: 19371583

Beaulieu et al (2006) Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice. Neuropsychopharmacology 281 32072 PMID: 16954211

Beaulieu et al (2005) An Akt/beta-arrestin 2/PP2A signaling complex mediates DArgic neurotransmission and behavior. Cell 122 261 PMID: 16051150

García-Fuster et al (2007) Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway. Proc Natl Acad Sci U S A 32 399 PMID: 16482086

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for SL 327

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.