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Submit ReviewSMER 28
说明： Positive regulator of autophagy
化学名： 6-Bromo-N-2-propenyl-4-quinazolinamine
纯度： ≥99% (HPLC)
生物活性 for SMER 28
SMER 28 is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T α-synuclein, associated with Huntington's and Parkinson's diseases, respectively. Promotes reprogramming of fibroblasts to neural stem-like cells in combination with other chemical reagents.
化合物库 for SMER 28
SMER 28 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for SMER 28
| 分子量 | 264.12 |
| 公式 | C11H10BrN3 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 307538-42-7 |
| PubChem ID | 1560402 |
| InChI Key | BCPOLXUSCUFDGE-UHFFFAOYSA-N |
| Smiles | C=CCNC2=NC=NC1=CC=C(Br)C=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SMER 28
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 26.41 | 100 |
制备储备液 for SMER 28
以下数据基于产品分子量 264.12。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.79 mL | 18.93 mL | 37.86 mL |
| 5 mM | 0.76 mL | 3.79 mL | 7.57 mL |
| 10 mM | 0.38 mL | 1.89 mL | 3.79 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.76 mL |
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产品说明书 for SMER 28
参考文献 for SMER 28
参考文献是支持产品生物活性的出版物。
Renna et al (2010) Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. J.Biol.Chem. 285 11061 PMID: 20147746
Sarkar et al (2010) Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat.Chem.Biol. 3 331 PMID: 17486044
Zhang et al (2016) Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 18 653 PMID: 27133794
If you know of a relevant reference for SMER 28, please let us know.
按产品操作查看相关产品
关键词: SMER 28, SMER 28 supplier, SMER28, autophagy, inducer, induces, modulates, MTOR-independent, small-molecule, enhancers, SMERs, Autophagy, Stem, Cell, Reprogramming, 4297, Tocris Bioscience
5 篇 SMER 28 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SMER 28 的部分引用包括：
Puri et al (2018) The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A. Dev Cell 45 114 PMID: 29634932
Zhang et al (2016) Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 18 653 PMID: 27133794
J K et al (2018) mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding. Cell 174 338-349.e20 PMID: 29937223
Cicero et al (2016) A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells. Sci Rep 6 34798 PMID: 27739443
Keith et al (2022) Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance. Nat Commun 13 4146 PMID: 35842429
您是否知道使用了 Tocris SMER 28 的优秀论文？ 请告知我们.
SMER 28 的评论
平均评分: 5 (Based on 1 Review.)
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Works good.
By
Anonymous on 06/25/2020
分析类型： In Vitro
种属： Mouse
细胞系/组织： Neural Stem Cells
M9 medium (10 µM SMER28)
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Autophagy Scientific Review
Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.
Autophagy Poster
Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.