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SNS 314 mesylate

Cat. No. 4584 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4584 has been discontinued.

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说明： Potent pan-Aurora kinase inhibitor
化学名： N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for SNS 314 mesylate

SNS 314 mesylate is a potent, ATP-competitive Aurora kinase inhibitor (IC50 values are 3, 9 and 31 nM for Aurora C, A and B, respectively). Exhibits both in vitro and in vivo activity against human cancer cell lines and tumor xenograft models. Displays additive antiproliferative effects in combination with chemotherapeutics such as carboplatin (Cat. No. 2626), gemcitabine (Cat. No. 3259) and 5-fluorouracil (Cat. No. 3257).

技术数据 for SNS 314 mesylate

分子量 527.04
公式 C18H15ClN6OS2.CH3SO3H
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1146618-41-8
PubChem ID 24995523
InChI Key FYCODPVDEFFWSR-UHFFFAOYSA-N
Smiles O=C(NC4=CC(Cl)=CC=C4)NC3=NC=C(S3)CCNC1=NC=NC2=C1SC=C2.CS(=O)(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for SNS 314 mesylate

分析证书/产品说明书
化学品安全技术说明书

参考文献 for SNS 314 mesylate

参考文献是支持产品生物活性的出版物。

Arbitrario et al (2010) SNS-314, a pan-Aurora kinase inhibitor, shows potent and anti-tumor activity and dosing flexibility in vivo. Cancer Chemother. Pharmacol. 65 707 PMID: 19649632

VanderPorten et al (2009) The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model. Mol.Cancer Ther. 8 930 PMID: 19372566

Oslob et al (2008) Discovery of a potent and selective Aurora kinase inhibitor. Bioorg.Med.Chem.Lett. 18 4880 PMID: 18678489

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关键词: SNS 314 mesylate, SNS 314 mesylate supplier, SNS314, mesylate, aurora, kinases, inhibitors, inhibits, potent, antiproliferatives, Aurora, Kinases, 4584, Tocris Bioscience

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