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Sorafenib

Cat. No. 6814 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT
化学名： 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Sorafenib

Sorafenib is a potent Raf inhibitor (IC50 values are 6, 22 and 38 nM for Raf-1, wild-type BRAF and V599E BRAF mutant, respectively). Also inhibits mVEGFR-2, mVEGFR-3, mPDGFR-β, Flt-3, cKIT and VEGFR-2 (IC50 values are 15, 20, 57, 58, 68 and 90 nM, respectively). Inhibits MAPK pathway in colon, pancreatic and breast cancer cells expressing mutant KRAS and mutant or wt BRAF in vitro. Exhibits antitumor activity in colon, breast and non small-cell lung cancer xenograft models. Also induces ferroptosis in hepatocellular carcinoma cells in vitro.

化合物库 for Sorafenib

Sorafenib is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Sorafenib

分子量 464.82
公式 C21H16ClF3N4O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 284461-73-0
PubChem ID 216239
InChI Key MLDQJTXFUGDVEO-UHFFFAOYSA-N
Smiles CNC(C1=CC(OC2=CC=C(C=C2)NC(NC3=CC(C(F)(F)F)=C(C=C3)Cl)=O)=CC=N1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Sorafenib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 9.3 20

制备储备液 for Sorafenib

以下数据基于产品分子量 464.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 10.76 mL 53.78 mL 107.57 mL
1 mM 2.15 mL 10.76 mL 21.51 mL
2 mM 1.08 mL 5.38 mL 10.76 mL
10 mM 0.22 mL 1.08 mL 2.15 mL

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参考文献 for Sorafenib

参考文献是支持产品生物活性的出版物。

Wilhelm et al (2004) BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 64 7099 PMID: 15466206

Lachaier et al (2014) Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors. Anticancer Res. 34 6417 PMID: 25368241

If you know of a relevant reference for Sorafenib, please let us know.

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关键词: Sorafenib, Sorafenib supplier, potent, Raf, inhibitors, multikinase, inhibits, BRAF, KRAS, MAPK, signaling, pathway, anticancer, VEGFR, PDGFR, beta, Flt-3, cKIT, Kinase, FLT3, Ferroptosis, 6814, Tocris Bioscience

1 篇 Sorafenib 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Sorafenib 的部分引用包括：

Grace et al (2022) Effect of CRISPR Knockout of AXIN1 or ARID1A on Proliferation and Migration of Porcine Hepatocellular Carcinoma. Front Oncol 12 904031 PMID: 35669430

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