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SPOP-i-6lc

Cat. No. 7498 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： SPOP E3 ubiquitin ligase inhibitor
化学名： 1,5-Dihydro-2-imino-10-methyl-N-[2-(4-methyl-1-piperazinyl)ethyl]-5-oxo-1-[2-(2-thienyl)ethyl]-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SPOP-i-6lc

SPOP-i-6lc is a selective SPOP E3 ubiquitin ligase inhibitor (IC50 = 2.1 μM and 3.5 μM, in A498 and OS-RC-2 cell lines, respectively). In vitro, SPOP-i-6lc suppresses viability and proliferation of A498 and OS-RC-2 kidney cancer cell lines. SPOP-i-6lc leads to the accumulation of tumor suppressors PTEN and DUSP7 and decreased levels of phosphorylated AKT and ERK in clear-cell renal cell carcinoma (ccRCC) cell lines.

技术数据 for SPOP-i-6lc

分子量 505.64
公式 C26H31N7O2S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2136270-56-7
PubChem ID 155532456
InChI Key CQWPQOGWIPGPOA-UHFFFAOYSA-N
Smiles CN1CCN(CC1)CCNC(C2=CC3=C(N(C2=N)CCC4=CC=CS4)N=C5N(C3=O)C=CC=C5C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SPOP-i-6lc

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 2.53 5
DMSO 5.06 10

制备储备液 for SPOP-i-6lc

以下数据基于产品分子量 505.64。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 19.78 mL 98.88 mL 197.77 mL
0.5 mM 3.96 mL 19.78 mL 39.55 mL
1 mM 1.98 mL 9.89 mL 19.78 mL
5 mM 0.4 mL 1.98 mL 3.96 mL

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参考文献 for SPOP-i-6lc

参考文献是支持产品生物活性的出版物。

Dong et al (2020) Structure-activity relationship of SPOP inhibitors against kidney cancer. J.Med.Chem. 63 4849 PMID: 32297747

If you know of a relevant reference for SPOP-i-6lc, please let us know.

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关键词: SPOP-i-6lc, SPOP-i-6lc supplier, spopi6lc, SPOP, E3, ubiquitin, ligase, inhibitors, inhibits, kidney, cancer, ligases, ubiquitination, prostate, Ubiquitin, Ligases, 7498, Tocris Bioscience

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