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Submit ReviewSR 3677 dihydrochloride
说明： Potent, selective Rho-kinase (ROCK) inhibitor
化学名： N-[2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl-2,3-dihydro-1,4-benzodioxin-2-carboxamide dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for SR 3677 dihydrochloride
SR 3677 dihydrochloride is a potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively).
化合物库 for SR 3677 dihydrochloride
SR 3677 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for SR 3677 dihydrochloride
| 分子量 | 481.37 |
| 公式 | C22H24N4O4.2HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1781628-88-3 |
| PubChem ID | 90255168 |
| InChI Key | INVVXEKRUDMEBE-UHFFFAOYSA-N |
| Smiles | O=C(C3COC(C=CC=C4)=C4O3)NC1=CC=C(C2=CNN=C2)C=C1OCCN(C)C.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SR 3677 dihydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 44.49 | 100 | |
| DMSO | 44.49 | 100 |
制备储备液 for SR 3677 dihydrochloride
以下数据基于产品分子量 481.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.08 mL | 10.39 mL | 20.77 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.15 mL |
| 10 mM | 0.21 mL | 1.04 mL | 2.08 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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产品说明书 for SR 3677 dihydrochloride
参考文献 for SR 3677 dihydrochloride
参考文献是支持产品生物活性的出版物。
Feng et al (2008) Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J.Med.Chem. 51 6642 PMID: 18834107
If you know of a relevant reference for SR 3677 dihydrochloride, please let us know.
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关键词: SR 3677 dihydrochloride, SR 3677 dihydrochloride supplier, potent, selective, Rho-kinase, ROCK, inhibitors, inhibits, Rho-associated, coiled-coil, kinases, stem, cells, SR3677, hydrochloride, Rho-kinases, Stem, Cell, Signaling, 3667, Tocris Bioscience
2 篇 SR 3677 dihydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SR 3677 dihydrochloride 的部分引用包括：
El-Sayed et al (2014) P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells. Front Microbiol 307 C83 PMID: 24760984
Lotz-Jenne et al (2016) A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor. Oncotarget 7 25983 PMID: 27036020
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
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Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.