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Src I1

Cat. No. 3642 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Dual site Src kinase inhibitor
化学名： 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Src I1

Src I1 is a potent, competitive dual site (ATP- and peptide-binding) Src kinase inhibitor (IC50 values are 44 and 88 nM for Src and Lck respectively). Inhibits VEGFR2 and c-fms at higher concentrations (IC50 values are 0.32 and 30 μM respectively). Can be used in parallel with PP 1 (Cat. No. 1397) and PP 2 (Cat. No. 1407) to inhibit Src family kinases.

化合物库 for Src I1

Src I1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Src I1

分子量 373.4
公式 C22H19N3O3
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 179248-59-0
PubChem ID 1474853
InChI Key DMWVGXGXHPOEPT-UHFFFAOYSA-N
Smiles COC(C(OC)=C3)=CC1=C3N=CN=C1NC2=CC=C(OC4=CC=CC=C4)C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Src I1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.34 100

制备储备液 for Src I1

以下数据基于产品分子量 373.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.39 mL 26.78 mL
5 mM 0.54 mL 2.68 mL 5.36 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for Src I1

参考文献是支持产品生物活性的出版物。

Bain et al (2007) The selectivity of protein kinase inhibitors: a further update. Biochem.J. 408 297 PMID: 17850214

Tian et al (2001) Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines. Biochem. 40 7084 PMID: 11401553

If you know of a relevant reference for Src I1, please let us know.

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关键词: Src I1, Src I1 supplier, Dual, site, Src, kinases, inhibitors, inhibits, Lck, family, SrcI1, Kinases, 3642, Tocris Bioscience

2 篇 Src I1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Src I1 的部分引用包括：

Zhang et al (2019) CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes. BMC Immunol 20 7 PMID: 30674283

Leung et al (2015) PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60. J Immunol 194 2930 PMID: 25687758

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