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Submit ReviewSRPIN340
说明： Selective SRPK1 inhibitor
化学名： N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide
纯度： ≥98% (HPLC)
生物活性 for SRPIN340
SRPIN340 is a selective serine arginine protein kinase (SRPK) 1 inhibitor (Ki = 0.89 μM). Inhibits SRPK2 at higher concentrations. Does not significantly inhibit other SRPKs such as CLK1 and CLK4, or other classes of SR kinases. Down-regulates expression of VEGF165 but does not affect VEGF165b expression.
技术数据 for SRPIN340
| 分子量 | 349.35 |
| 公式 | C18H18F3N3O |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 218156-96-8 |
| PubChem ID | 2797577 |
| InChI Key | DWFGGOFPIISJIT-UHFFFAOYSA-N |
| Smiles | O=C(C3=CC=NC=C3)NC1=C(N2CCCCC2)C=CC(C(F)(F)F)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SRPIN340
参考文献 for SRPIN340
参考文献是支持产品生物活性的出版物。
Gammons et al (2013) SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity. Invest.Ophthalmol.Vis.Sci. 54 5797 PMID: 23761094
Fukuhara et al (2006) Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc.Natl.Acad.Sci.USA 103 11329 PMID: 16840555
Oltean et al (2012) SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for multiple diseases. Biochem.Soc.Trans. 40 831 PMID: 22817743
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关键词: SRPIN340, SRPIN340 supplier, SR, Protein, Kinase, inhibitors, Phosphorylation, Inhibitor, 340(SRPIN)340, Serine-Arginine-Rich, inhibits, SRPK1, SRPK2, Other, Kinases, 5063, Tocris Bioscience
2 篇 SRPIN340 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SRPIN340 的部分引用包括：
Lucas et al (2018) Kinase-controlled phase transition of membraneless organelles in mitosis. Nature 559 211-216 PMID: 29973724
Katarzyna et al (2022) Stimulus-specific remodeling of the neuronal transcriptome through nuclear intron-retaining transcripts. EMBO J 41 e110192 PMID: 36149731
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