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STOCK2S 26016

Cat. No. 5570 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Lysine deficient protein kinase (WNK) signaling inhibitor
化学名： 7-Ethoxy-N3-(2-furanylmethyl)-3,9-acridinediamine
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for STOCK2S 26016

STOCK2S 26016 is a lysine deficient protein kinase (WNK) signaling inhibitor (IC50 = 16 μM). Inhibits binding of WNK1 and WNK4 to SPAK and phosphorylation of downstream transporters, NKCC1 and NCC, in mouse vascular smooth muscle and distal convoluted tubule cell cultures exposed to hypotonic shock, respectively. Inhibits STK39 activation; inhibits migration and invasion of cancer cells in vitro.

技术数据 for STOCK2S 26016

分子量 333.38
公式 C20H19N3O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 332922-63-1
PubChem ID 3135086
InChI Key PGNWQNJXXLPZEL-UHFFFAOYSA-N
Smiles NC1=C2C(C=CC(OCC)=C2)=NC3=C1C=CC(NCC4=CC=CO4)=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for STOCK2S 26016

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 33.34 100
ethanol 16.67 50

制备储备液 for STOCK2S 26016

以下数据基于产品分子量 333.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3 mL 15 mL 30 mL
5 mM 0.6 mL 3 mL 6 mL
10 mM 0.3 mL 1.5 mL 3 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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参考文献 for STOCK2S 26016

参考文献是支持产品生物活性的出版物。

Mori et al (2013) Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy. Biochem.J. 455 339 PMID: 23981180

Qiu et al (2021) STK39 promotes breast cancer invasion and metastasis by increasing SNAI1 activity upon phosphorylation. Theranostics 11 7658 PMID: 34335956

If you know of a relevant reference for STOCK2S 26016, please let us know.

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关键词: STOCK2S 26016, STOCK2S 26016 supplier, with, no, lysine, deficient, protein, kinase, WNK1, WNK4, SPAK, signaling, inhibitors, inhibits, antihypertensive, Other, Kinases, 5570, Tocris Bioscience

3 篇 STOCK2S 26016 的引用文献

引用文献是使用了 Tocris 产品的出版物。 STOCK2S 26016 的部分引用包括：

Hortle et al (2022) OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection. Life Sci.Alliance 5 e202201476 PMID: 35545295

Qiu et al (2021) STK39 promotes breast cancer invasion and metastasis by increasing SNAI1 activity upon phosphorylation. Theranostics 11 7658 PMID: 34335956

Lu et al (2019) The role of WNK in modulation of KCl cotransport activity in red cells from normal individuals and patients with sickle cell anaemia. Pflugers Arch. 471 1539 PMID: 31729557

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