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Submit ReviewStreptozocin
说明： DNA alkylator; antitumor and induces diabetes
别名： Streptozotocin
化学名： 2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose
纯度： ≥95% (HPLC)
生物活性 for Streptozocin
Streptozocin is an antibiotic and antitumor agent. Alkylates DNA and induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic β-cells in vivo.
技术数据 for Streptozocin
| 分子量 | 265.22 |
| 公式 | C8H15N3O7 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 18883-66-4 |
| PubChem ID | 2733335 |
| InChI Key | ZSJLQEPLLKMAKR-YDEIVXIUSA-N |
| Smiles | O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(N(C)N=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Streptozocin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 26.52 | 100 | |
| DMSO | 26.52 | 100 |
制备储备液 for Streptozocin
以下数据基于产品分子量 265.22。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.77 mL | 18.85 mL | 37.7 mL |
| 5 mM | 0.75 mL | 3.77 mL | 7.54 mL |
| 10 mM | 0.38 mL | 1.89 mL | 3.77 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
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产品说明书 for Streptozocin
参考文献 for Streptozocin
参考文献是支持产品生物活性的出版物。
Bennett and Pegg (1981) Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 41 2786 PMID: 6454479
Weis (1982) Steptozotocin: A review of its pharmacology, efficacy and toxicity. Cancer Treat. Rep. 66 427 PMID: 6277485
If you know of a relevant reference for Streptozocin, please let us know.
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关键词: Streptozocin, Streptozocin supplier, DNA, alkylators, antitumor, antitmour, induces, diabetes, Apoptosis, Inducers, antibiotics, chemotherapeutics, Streptozotocin, Antibiotics, 1621, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Streptozocin (streptozotocin), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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Streptozocin 的评论
平均评分: 5 (Based on 1 Review.)
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Streptozocin used on GLUT2 positive neuroendocrine tumor cells.
By
Anonymous on 02/18/2019
种属： Human
细胞系/组织： GLUT2 positive neuroendocrine tumor cells
Streptozocin used on GLUT2 positive neuroendocrine tumor cells.Streptozocin was used to induce type 1 diabetes
该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Programmed Cell Death Poster
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Pathways for Streptozocin
