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SZL P1-41

Cat. No. 5076 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective Skp2 inhibitor; suppresses E3 ligase activity
化学名： 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SZL P1-41

SZL P1-41 is a Skp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.

技术数据 for SZL P1-41

分子量 420.52
公式 C24H24N2O3S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 222716-34-9
PubChem ID 1286902
InChI Key JKIXLEKBXHMXTN-UHFFFAOYSA-N
Smiles OC(C(CC)=C2)=C(CN3CCCCC3)C1=C2C(C(C4=NC5=C(C=CC=C5)S4)=CO1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SZL P1-41

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1eq. HCl 8.41 20
DMSO 2.1 5 温和加热

制备储备液 for SZL P1-41

以下数据基于产品分子量 420.52。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 11.89 mL 59.45 mL 118.9 mL
1 mM 2.38 mL 11.89 mL 23.78 mL
2 mM 1.19 mL 5.95 mL 11.89 mL
10 mM 0.24 mL 1.19 mL 2.38 mL

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参考文献 for SZL P1-41

参考文献是支持产品生物活性的出版物。

Chan et al (2013) Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell 154 556 PMID: 23911321

If you know of a relevant reference for SZL P1-41, please let us know.

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关键词: SZL P1-41, SZL P1-41 supplier, SZLP1-41, Selective, Skp2, inhibitors, inhibits, suppresses, E3, ligase, SCF, complexes, antitumor, p27, Akt, ubiquitination, cell, senescence, glycolysis, Ubiquitin, Ligases, 5076, Tocris Bioscience

1 篇 SZL P1-41 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SZL P1-41 的部分引用包括：

Jang et al (2017) Mechanical cue-induced YAP instructs Skp2-dependent cell cycle exit and oncogenic signaling. EMBO J 36 2510 PMID: 28673931

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