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TC-DAPK 6

Cat. No. 4301 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective inhibitor of DAPK1
化学名： (4Z)-2-[(E)-2-Phenylethenyl)-4-(3-pyridinylmethylene)-5(4H)-oxazolone
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TC-DAPK 6

TC-DAPK 6 is a potent and selective, ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) (IC50 values are 69 and 225 nM for DAPK1 and DAPK3 respectively, when assayed with 10 μM ATP). Displays selectivity for DAPK1 over a range of 48 other kinases, including Abl, AMPK, Chk1, Met and Src (IC50 > 10 μM).

化合物库 for TC-DAPK 6

TC-DAPK 6 is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for TC-DAPK 6

分子量 276.29
公式 C17H12N2O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 2439180-90-0
PubChem ID 2360773
InChI Key GFGMISOSPOPSHN-NOCYUORASA-N
Smiles O=C1OC(/C=C/C3=CC=CC=C3)=N\C1=C/C2=CC=CN=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC-DAPK 6

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 13.81 50

制备储备液 for TC-DAPK 6

以下数据基于产品分子量 276.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 7.24 mL 36.19 mL 72.39 mL
2.5 mM 1.45 mL 7.24 mL 14.48 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
25 mM 0.14 mL 0.72 mL 1.45 mL

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参考文献 for TC-DAPK 6

参考文献是支持产品生物活性的出版物。

Okamoto et al (2009) Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J.Med.Chem. 52 7323 PMID: 19877644

If you know of a relevant reference for TC-DAPK 6, please let us know.

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关键词: TC-DAPK 6, TC-DAPK 6 supplier, TC-DAPK6, death-associated, protein, kinase, dapk1, selective, potent, inhibitors, inhibits, 315694-89-4, DAPK, 4301, Tocris Bioscience

1 篇 TC-DAPK 6 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TC-DAPK 6 的部分引用包括：

Michael R et al (2020) DAPK1 Promotes Extrasynaptic GluN2B Phosphorylation and Striatal Spine Instability in the YAC128 Mouse Model of Huntington Disease. Front Cell Neurosci 14 590569 PMID: 33250715

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