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TC-S 7003

Cat. No. 3567 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent Lck inhibitor
化学名： 6-(2,6-Dimethylphenyl)-2-[[4-(4-methyl-1-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TC-S 7003

TC-S 7003 is a potent inhibitor of lymphocyte specific kinase (Lck). IC50 values are 0.007, 0.021, 0.042 and 0.20 μM for Lck, Lyn, Src and Syk kinases respectively. Displays >1000-fold selectivity for Lck over MAPK, CDK and RSK family representatives. Inhibits T cell proliferation in vitro and inhibits arthritis in two in vivo models. Orally active.

化合物库 for TC-S 7003

TC-S 7003 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for TC-S 7003

分子量 530.62
公式 C31H30N8O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 847950-09-8
PubChem ID 11785878
InChI Key BHJJWVDKNXABFS-UHFFFAOYSA-N
Smiles O=C3N(C4=C(C)C=CC=C4C)C1=NC7=C(C=CC=C7)N1C2=NC(NC5=CC=C(N6CCN(C)CC6)C=C5)=NC=C23

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC-S 7003

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 53.06 100
ethanol 5.31 10 温和加热

制备储备液 for TC-S 7003

以下数据基于产品分子量 530.62。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.88 mL 9.42 mL 18.85 mL
5 mM 0.38 mL 1.88 mL 3.77 mL
10 mM 0.19 mL 0.94 mL 1.88 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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参考文献 for TC-S 7003

参考文献是支持产品生物活性的出版物。

Martin et al (2008) Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory J.Med.Chem. 51 1637 PMID: 18278858

If you know of a relevant reference for TC-S 7003, please let us know.

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关键词: TC-S 7003, TC-S 7003 supplier, Lck, kinases, inhibitors, inhibits, lymphocyte, specific, Src, Kinases, 3567, Tocris Bioscience

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