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说明： Potent and selective DYRK1A/B inhibitor
化学名： N-[2-Chloro-5-[[[(3-chlorophenyl)methyl]amino]carbonyl]phenyl]-7,8-dihydro-2-methoxy-7-oxopyrido[2,3-d]pyrimidine-6-carboxamide
纯度： ≥98% (HPLC)
生物活性 for TC-S 7004
TC-S 7004 is a potent and selective DYRK1A/B inhibitor (IC50 values are 22 and 68 nM respectively). Selective for DYRK1A/B over a panel of other kinases. Reduces accumulation of quiescent Panc1 pancreatic cancer cells in G0 under serum free conditions. Also induces DNA damage and apoptosis in quiescent Panc1 cells.
化合物库 for TC-S 7004
TC-S 7004 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。
技术数据 for TC-S 7004
| 分子量 | 498.32 |
| 公式 | C23H17Cl2N5O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1386979-55-0 |
| PubChem ID | 57523919 |
| InChI Key | CQKBSRPVZZLCJE-UHFFFAOYSA-N |
| Smiles | O=C(NC3=CC(C(NCC4=CC(Cl)=CC=C4)=O)=CC=C3Cl)C2=CC1=CN=C(OC)N=C1NC2=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for TC-S 7004
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 49.83 | 100 |
制备储备液 for TC-S 7004
以下数据基于产品分子量 498.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.01 mL | 10.03 mL | 20.07 mL |
| 5 mM | 0.4 mL | 2.01 mL | 4.01 mL |
| 10 mM | 0.2 mL | 1 mL | 2.01 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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产品说明书 for TC-S 7004
参考文献 for TC-S 7004
参考文献是支持产品生物活性的出版物。
Ewton et al (2011) Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. Mol.Cancer Ther. 10 2104 PMID: 21878655
Anderson et al (2013) Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg.Med.Chem.Lett. 15 6610 PMID: 24239188
If you know of a relevant reference for TC-S 7004, please let us know.
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关键词: TC-S 7004, TC-S 7004 supplier, TC-S7004, Mirk, DYRK1B, DYRK1A, potent, inhibitors, inhibits, DYRK, 5088, Tocris Bioscience
1 篇 TC-S 7004 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TC-S 7004 的部分引用包括：
Blake et al (2019) Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer. Sci Signal 12 PMID: 31311847
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