TCS 2002

Cat. No. 3869 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent GSK-3β inhibitor

化学名： 2-Methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]-1,3,4-oxadiazole

纯度： ≥99% (HPLC)

引用文献 (1)

文献 (4)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TCS 2002

TCS 2002 is a potent inhibitor of GSK-3β (IC₅₀ = 35 nM). Oral adminstration inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain.

化合物库 for TCS 2002

TCS 2002 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TCS 2002

分子量	338.38
公式	C₁₈H₁₄N₂O₃S
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	1005201-24-0
PubChem ID	24855958
InChI Key	RCKYSTKYIVULEK-UHFFFAOYSA-N
Smiles	O=S(C)C(C=C3)=CC=C3C2=COC1=CC=C(C4=NN=C(C)O4)C=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TCS 2002

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	33.84	100
	ethanol	8.46	25

制备储备液 for TCS 2002

以下数据基于产品分子量 338.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.78 mL	29.55 mL
5 mM	0.59 mL	2.96 mL	5.91 mL
10 mM	0.3 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.3 mL	0.59 mL

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产品说明书 for TCS 2002

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TCS 2002

参考文献是支持产品生物活性的出版物。

Saitoh et al (2009) 2-{3-[4-(alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β with good brain permeability. J.Med.Chem. 52 6270 PMID: 19775160

If you know of a relevant reference for TCS 2002, please let us know.

按标靶查看相关产品

关键词: TCS 2002, TCS 2002 supplier, TCS2002, glycogen, synthase, kinases, gsk-3, gsk3, gsk-3beta, gsk-3b, gsk-3β, inhibitors, inhibits, Glycogen, Synthase, Kinase, 3, 3869, Tocris Bioscience

1 篇 TCS 2002 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TCS 2002 的部分引用包括：

Bellio et al (2017) Hypoxic Stress Decreases c-Myc Protein Stability in Cardiac Progenitor Cells Inducing Quiescence and Compromising Their Proliferative and Vasculogenic Potential. Sci Rep 7 9702 PMID: 28851980

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