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TCS PIM-1 1

Cat. No. 2979 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective, ATP-competitive Pim-1 kinase inhibitor
别名： SC 204330
化学名： 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TCS PIM-1 1

TCS PIM-1 1 is an ATP-competitive Pim-1 kinase inhibitor that displays selectivity over Pim-2 and MEK1/2 (IC50 values are 50, > 20000 and > 20000 nM for Pim-1, Pim-2 and MEK1/2 respectively).

化合物库 for TCS PIM-1 1

TCS PIM-1 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for TCS PIM-1 1

分子量 367.2
公式 C18H11BrN2O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 491871-58-0
PubChem ID 1235170
InChI Key SVSYJTYGPLVUOZ-UHFFFAOYSA-N
Smiles OC1=C(C2=CC(C3=CC=CC=C3)=C(C#N)C(N2)=O)C=C(Br)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TCS PIM-1 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.72 100

制备储备液 for TCS PIM-1 1

以下数据基于产品分子量 367.2。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.62 mL 27.23 mL
5 mM 0.54 mL 2.72 mL 5.45 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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产品说明书 for TCS PIM-1 1

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for TCS PIM-1 1

参考文献是支持产品生物活性的出版物。

Cheney et al (2007) Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg.Med.Chem.Letts. 17 1679 PMID: 17251021

If you know of a relevant reference for TCS PIM-1 1, please let us know.

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关键词: TCS PIM-1 1, TCS PIM-1 1 supplier, Selective, ATP-competitive, Pim-1, kinases, inhibitors, inhibits, TCSPIM11, SC, 204330, Pim, Kinase, 2979, Tocris Bioscience

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